PMID- 27908556
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20171204
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 26
IP  - 5
DP  - 2017 May
TI  - The Relationship between Neutrophil-to-Lymphocyte Ratio and Intracerebral 
      Hemorrhage in Type 2 Diabetes Mellitus.
PG  - 930-937
LID - S1052-3057(16)30444-X [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2016.10.041 [doi]
AB  - INTRODUCTION: Chronic systematic inflammation has been suggested to be associated 
      with the occurrence and development of cardiovascular events. Low-grade 
      systematic inflammation persists in type 2 diabetes mellitus (T2DM) patients. In 
      addition, the risk of cerebral hemorrhage in these patients is increased compared 
      with non-diabetic patients. Neutrophil-to-lymphocyte ratio (NLR) is the ratio 
      derived by dividing the neutrophil count with the lymphocyte count from a 
      peripheral blood sample. This study aimed to explore the relation between NLR and 
      cerebral hemorrhage, and to prove that NLR is an independent risk factor of 
      cerebral hemorrhage in T2DM patients. METHODS: In total, 429 cases of T2DM 
      patients were included. The patients were divided into two groups depending on 
      the presence of cerebral hemorrhage: the cerebral hemorrhage group (n = 87) and 
      the control group (n = 342). Based on clinical and laboratory data of diabetes 
      diagnosis, this article investigates the relationship between NLR and the risk of 
      cerebral hemorrhage. RESULTS: Increase in NLR was positively correlated with the 
      incidence of cerebral hemorrhage in T2DM patients and might serve as an 
      independent risk factor of cerebral hemorrhage in T2DM patients (OR: 4.451, 95% 
      CI: 2.582-7.672). NLR >2.58 might be useful in predicting the threshold value of 
      cerebral hemorrhage risk in newly diagnosed T2DM patients (area under the curve: 
      .72, 95% CI: .659-.780, P < .001) CONCLUSION: As an indicator of the degree of 
      systematic inflammation, NLR is an independent risk factor of cerebral hemorrhage 
      in T2DM patients.
CI  - Copyright (c) 2017 National Stroke Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Luo, Peng
AU  - Luo P
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Li, Rui
AU  - Li R
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Yu, Siyuan
AU  - Yu S
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Xu, Tingting
AU  - Xu T
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Yue, Shufan
AU  - Yue S
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Ji, Yongli
AU  - Ji Y
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, China.
FAU - Chen, Xin
AU  - Chen X
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic 
      address: chen_xin1020@163.com.
FAU - Xie, Haiting
AU  - Xie H
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic 
      address: zjyysjnk@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20161128
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
SB  - IM
MH  - Aged
MH  - Area Under Curve
MH  - Cerebral Hemorrhage/*blood/diagnosis/etiology
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/*blood/complications/diagnosis
MH  - Female
MH  - Humans
MH  - Inflammation/*blood/complications/diagnosis
MH  - Logistic Models
MH  - Lymphocyte Count
MH  - *Lymphocytes
MH  - Male
MH  - Middle Aged
MH  - *Neutrophils
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Intracerebral hemorrhage
OT  - inflammation
OT  - neutrophil-to-lymphocyte ratio
OT  - type 2 diabetes mellitus
EDAT- 2016/12/03 06:00
MHDA- 2017/12/05 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/08/13 00:00 [received]
PHST- 2016/10/26 00:00 [revised]
PHST- 2016/10/31 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - S1052-3057(16)30444-X [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2016.10.041 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2017 May;26(5):930-937. doi: 
      10.1016/j.jstrokecerebrovasdis.2016.10.041. Epub 2016 Nov 28.