PMID- 27908565
OWN - NLM
STAT- MEDLINE
DCOM- 20180517
LR  - 20191210
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 36
IP  - 5
DP  - 2017 Oct
TI  - Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A 
      population-based study and systematic review.
PG  - 1215-1230
LID - S0261-5614(16)31327-9 [pii]
LID - 10.1016/j.clnu.2016.11.011 [doi]
AB  - AIMS: Hyperhomocysteinemia (HHcy) is known to increase the risk of many diseases. 
      Factors influencing HHcy in healthy and hypertensive subjects remain 
      under-researched. METHODS: A large population-based study was conducted in 60 
      communities from Shenzhen, China. Responses to standardized questions on 
      lifestyle factors and blood samples were collected from all participants after a 
      12-h overnight fast. Multiple linear and multivariate logistic regressions were 
      used to explore risk factors for HHcy. Results were then compared to those from a 
      systematic review of English-language articles listed in Pubmed, EBSCOhost, Web 
      of Science, Embase and Cochrane libraries that investigated HHcy risk factors in 
      healthy and hypertensive subjects. RESULTS: A total of 1586 healthy 
      (Male/Female = 642/944) and 5935 hypertensive subjects (Male/Female = 2928/3007) 
      participated in our population-based study. In logistic regression analyses, age, 
      BMI and creatinine (Cr) were risk factors, while being female, fruit intake and 
      physical activity were protective factors for HHcy in healthy subjects. In 
      hypertensive subjects, seven [age, smoking, salt intake, systolic blood pressure 
      (SBP), uric acid, triglycerides (TG), and Cr] and four [female, fruit intake, 
      total cholesterol (TC), and glucose] factors were associated with higher and 
      lower HHcy respectively. The review of 71 studies revealed that potential risk 
      factors for Hcy included nutritional, physiologic, lifestyle habits, ethnicity, 
      genetics, interactions between gene-environment, gene-gene, gene-nutritional, 
      environment-environment, nutritional-nutritional. CONCLUSION: Our study indicates 
      the potential importance of increasing folic acid and vitamin B supplementation, 
      daily fruit and vegetable intake, regular exercise and refraining from tobacco 
      smoking and alcohol consumption as preventive strategies for Hcy.
CI  - Copyright (c) 2016 Elsevier Ltd and European Society for Clinical Nutrition and 
      Metabolism. All rights reserved.
FAU - Han, Liyuan
AU  - Han L
AD  - School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 
      University, Ningbo, 315211, China.
FAU - Liu, Yanfen
AU  - Liu Y
AD  - School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 
      University, Ningbo, 315211, China.
FAU - Wang, Changyi
AU  - Wang C
AD  - Department of Chronic Disease Prevention and Control, Shenzhen Nanshan Center for 
      Chronic Disease Control, Shenzhen, 518054, China.
FAU - Tang, Linlin
AU  - Tang L
AD  - Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 
      Zhejiang, 310000, China.
FAU - Feng, Xiaoqi
AU  - Feng X
AD  - Population Wellbeing and Environment Research Lab (PowerLab), Faculty of Social 
      Sciences, University of Wollongong, NSW, 2522, Australia; Early Start Research 
      Institute, Faculty of Social Sciences, University of Wollongong, Wollongong, NSW, 
      2522, Australia.
FAU - Astell-Burt, Thomas
AU  - Astell-Burt T
AD  - Population Wellbeing and Environment Research Lab (PowerLab), Faculty of Social 
      Sciences, University of Wollongong, NSW, 2522, Australia; Early Start Research 
      Institute, Faculty of Social Sciences, University of Wollongong, Wollongong, NSW, 
      2522, Australia.
FAU - Wen, Qi
AU  - Wen Q
AD  - Department of Chronic Disease Prevention and Control, Shenzhen Nanshan Center for 
      Chronic Disease Control, Shenzhen, 518054, China.
FAU - Duan, Donghui
AU  - Duan D
AD  - School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 
      University, Ningbo, 315211, China.
FAU - Lu, Nanjia
AU  - Lu N
AD  - School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 
      University, Ningbo, 315211, China.
FAU - Xu, Guodong
AU  - Xu G
AD  - School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 
      University, Ningbo, 315211, China.
FAU - Wang, Kaiyue
AU  - Wang K
AD  - School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 
      University, Ningbo, 315211, China.
FAU - Zhang, Lu
AU  - Zhang L
AD  - School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 
      University, Ningbo, 315211, China.
FAU - Gu, Kaibo
AU  - Gu K
AD  - School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 
      University, Ningbo, 315211, China.
FAU - Chen, Sihan
AU  - Chen S
AD  - Department of Chronic Disease Prevention and Control, Shenzhen Nanshan Center for 
      Chronic Disease Control, Shenzhen, 518054, China.
FAU - Ma, Jianping
AU  - Ma J
AD  - Department of Chronic Disease Prevention and Control, Shenzhen Nanshan Center for 
      Chronic Disease Control, Shenzhen, 518054, China.
FAU - Zhang, Tao
AU  - Zhang T
AD  - Department of Chronic Disease Prevention and Control, Shenzhen Nanshan Center for 
      Chronic Disease Control, Shenzhen, 518054, China.
FAU - You, Dingyun
AU  - You D
AD  - Department of Science and Technology, Kunming Medical University, Kunming, 
      650500, China. Electronic address: youdingyun@qq.com.
FAU - Duan, Shiwei
AU  - Duan S
AD  - School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 
      University, Ningbo, 315211, China. Electronic address: duanshiwei@nbu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20161119
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 0 (Triglycerides)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 268B43MJ25 (Uric Acid)
RN  - 935E97BOY8 (Folic Acid)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Blood Pressure
MH  - Body Mass Index
MH  - China
MH  - Creatinine/blood
MH  - Diet, Healthy
MH  - Dietary Supplements
MH  - Exercise
MH  - Female
MH  - Folic Acid/administration & dosage/blood
MH  - Fruit
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*diagnosis/*epidemiology
MH  - Hypertension/blood/*epidemiology
MH  - Life Style
MH  - Male
MH  - Risk Factors
MH  - Triglycerides/blood
MH  - Uric Acid/blood
MH  - Vegetables
MH  - Vitamin B Complex/administration & dosage/blood
OTO - NOTNLM
OT  - Healthy
OT  - Homocysteine
OT  - Hyperhomocysteinemia
OT  - Hypertension
EDAT- 2016/12/03 06:00
MHDA- 2018/05/18 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/05/17 00:00 [received]
PHST- 2016/10/16 00:00 [revised]
PHST- 2016/11/11 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2018/05/18 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - S0261-5614(16)31327-9 [pii]
AID - 10.1016/j.clnu.2016.11.011 [doi]
PST - ppublish
SO  - Clin Nutr. 2017 Oct;36(5):1215-1230. doi: 10.1016/j.clnu.2016.11.011. Epub 2016 
      Nov 19.