PMID- 27908667
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20180112
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 220
IP  - 2 Pt B
DP  - 2017 Apr
TI  - Concentrations of polychlorinated dibenzodioxins, polychlorodibenzofurans, and 
      polychlorobiphenyls in women of reproductive age in Italy: A human biomonitoring 
      study.
PG  - 378-386
LID - S1438-4639(16)30287-5 [pii]
LID - 10.1016/j.ijheh.2016.11.009 [doi]
AB  - BACKGROUND: Polychlorinated dibenzodioxins (PCDDs), polychlorodibenzofurans 
      (PCDFs), and polychlorobiphenyls (PCBs) are persistent organic pollutants that 
      represent a major concern for women of reproductive age because of the 
      neurodevelopmental effects associated to perinatal exposure. OBJECTIVES: This 
      study was aimed at characterizing exposure of women of reproductive age to PCDDs, 
      PCDFs, and PCBs as a function of residence in different Italian Regions, in areas 
      at presumable different environmental contamination and human exposure to these 
      pollutants. METHODS: Study participants were enrolled in 2011-2012 in 6 Italian 
      Regions representative of Northern, Central and Southern Italy; in each region, 
      areas at presumed different exposure (rural, urban and industrial) were selected 
      for enrolment. Each participant provided a serum sample for the analysis of 
      PCDDs, PCDFs and PCBs. RESULTS: Median concentrations of PCDDs+PCDFs, DL-PCBs, 
      NDL(6)-PCBs and NDL(9)-PCBs in serum samples were respectively 6.0 and 3.5 
      pgWHO-TE(05)/g fat, and 75 and 93ng/g fat. Age was the variable that most 
      affected median serum concentrations. Age adjusted concentrations were found 
      significantly different between geographical zones: women from Northern Italy 
      showed the highest values, followed by Central and Southern Italy. PCDDs+PCDFs 
      concentrations were significantly higher in the group of women residing in 
      industrial areas compared to the group residing in rural areas. A clear 
      diminishing temporal trend was observed compared to levels reported in previous 
      studies. CONCLUSIONS: This study produced the largest dataset on serum 
      concentrations of PCDDs, PCDFs and PCBs in women of childbearing age in Italy. 
      RESULTS: confirmed that environmental and lifestyle factors may influence 
      exposure to these contaminants and thereby the body burden. The observed marked 
      temporal decline in body burden during three decades is in agreement with the 
      general trend observed worldwide.
CI  - Copyright (c) 2016 Elsevier GmbH. All rights reserved.
FAU - Ingelido, Anna Maria
AU  - Ingelido AM
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy.
FAU - Abate, Vittorio
AU  - Abate V
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy.
FAU - Abballe, Annalisa
AU  - Abballe A
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy. Electronic address: annalisa.abballe@iss.it.
FAU - Albano, Fulvia Lucia
AU  - Albano FL
AD  - Ospedale Ostetrico Ginecologico Sant'Anna, Citta della Salute e della Scienza, 
      Torino, Italy.
FAU - Battista, Tatiana
AU  - Battista T
AD  - ASL Taranto, Dipartimento Prevenzione, Taranto, Italy.
FAU - Carraro, Valter
AU  - Carraro V
AD  - Azienda Provinciale per i Servizi Sanitari della Provincia Autonoma di Trento, 
      Unita Operativa Igiene e Sanita Pubblica, Trento, Italy.
FAU - Conversano, Michele
AU  - Conversano M
AD  - ASL Taranto, Dipartimento Prevenzione, Taranto, Italy.
FAU - Corvetti, Rosa
AU  - Corvetti R
AD  - ASL Umbria 2, Terni, Italy.
FAU - De Luca, Silvia
AU  - De Luca S
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy.
FAU - Franchini, Silva
AU  - Franchini S
AD  - Azienda Provinciale per i Servizi Sanitari della Provincia Autonoma di Trento, 
      Unita Operativa Igiene e Sanita Pubblica, Trento, Italy.
FAU - Fulgenzi, Anna Rita
AU  - Fulgenzi AR
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy.
FAU - Giambanco, Laura
AU  - Giambanco L
AD  - Azienda di rilievo Nazionale e di Alta Specializzazione, Ospedale Civico di 
      Palermo, U.O.C. di Ginecologia e Ostetricia, Palermo, Italy.
FAU - Iacovella, Nicola
AU  - Iacovella N
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy.
FAU - Iamiceli, Anna Laura
AU  - Iamiceli AL
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy.
FAU - Maiorana, Antonio
AU  - Maiorana A
AD  - Azienda di rilievo Nazionale e di Alta Specializzazione, Ospedale Civico di 
      Palermo, U.O.C. di Ginecologia e Ostetricia, Palermo, Italy.
FAU - Maneschi, Francesco
AU  - Maneschi F
AD  - Azienda Sanitaria Locale di Latina, P.O. Nord "S. Maria Goretti", U.O.C. 
      Ostetricia e Ginecologia, Latina, Italy.
FAU - Marra, Valentina
AU  - Marra V
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy.
FAU - Pirola, Flavia
AU  - Pirola F
AD  - ASST, Lecco, Italy.
FAU - Porpora, Maria Grazia
AU  - Porpora MG
AD  - Dipartimento di Scienze Ginecologiche e Ostetriche e Scienze Urologiche - 
      Universita di Roma, "Sapienza" Roma, Italy.
FAU - Procopio, Enrico
AU  - Procopio E
AD  - ASL 5 Susa (To), Italy.
FAU - Suma, Nicola
AU  - Suma N
AD  - ASL 5 Susa (To), Italy.
FAU - Valentini, Silvia
AU  - Valentini S
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy.
FAU - Valsenti, Luisa
AU  - Valsenti L
AD  - ASL Umbria 2, Terni, Italy.
FAU - Vecchie, Valerio
AU  - Vecchie V
AD  - ASL 5 Pinerolo (To), Italy.
FAU - De Felip, Elena
AU  - De Felip E
AD  - Istituto Superiore di Sanita, Dipartimento Ambiente e connessa Prevenzione 
      Primaria, Roma, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161124
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Benzofurans)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Polymers)
RN  - 0 (polychlorodibenzofuran)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Benzofurans/*blood
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Italy
MH  - Polychlorinated Biphenyls/*blood
MH  - Polychlorinated Dibenzodioxins/*blood
MH  - Polymers
MH  - Young Adult
OTO - NOTNLM
OT  - Human biomonitoring
OT  - Italy
OT  - PCBs
OT  - PCDDs
OT  - PCDFs
OT  - Women
EDAT- 2016/12/03 06:00
MHDA- 2017/09/12 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/09/01 00:00 [received]
PHST- 2016/11/14 00:00 [revised]
PHST- 2016/11/23 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - S1438-4639(16)30287-5 [pii]
AID - 10.1016/j.ijheh.2016.11.009 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2017 Apr;220(2 Pt B):378-386. doi: 
      10.1016/j.ijheh.2016.11.009. Epub 2016 Nov 24.