PMID- 27908701
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20170314
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 99
DP  - 2017 Jan
TI  - Inhibitory effects of l-theanine on airway inflammation in ovalbumin-induced 
      allergic asthma.
PG  - 162-169
LID - S0278-6915(16)30450-1 [pii]
LID - 10.1016/j.fct.2016.11.032 [doi]
AB  - l-theanine, a water-soluble amino acid isolated from green tea (Camellia 
      sinensis), has anti-inflammatory activity, antioxidative properties, and 
      hepatoprotective effects. However, the anti-allergic effect of l-theanine and its 
      underlying molecular mechanisms have not been elucidated. In this study, we 
      investigated the protective effects of l-theanine on asthmatic responses, 
      particularly airway inflammation and oxidative stress modulation in an ovalbumin 
      (OVA)-induced murine model of asthma. Treatment with l-theanine dramatically 
      attenuated the extensive trafficking of inflammatory cells into bronchoalveolar 
      lavage fluid (BALF). Histological studies revealed that l-theanine significantly 
      inhibited OVA-induced mucus production and inflammatory cell infiltration in the 
      respiratory tract and blood vessels. l-theanine administration also significantly 
      decreased the production of IgE, monocyte chemoattractant protein-1 (MCP-1), 
      interleukin (IL)-4, IL-5, IL-13, tumor necrosis factor-alpha (TNF-alpha), and 
      interferon-gamma in BALF. The lung weight decreased with l-theanine 
      administration. l-theanine also markedly attenuated the OVA-induced generation of 
      reactive oxygen species and the activation of nuclear factor kappa B (NF-kappaB) and 
      matrix metalloprotease-9 in BALF. Moreover, l-theanine reduced the TNF-alpha-induced 
      NF-kappaB activation in A549 cells. Together, these results suggest that l-theanine 
      alleviates airway inflammation in asthma, which likely occurs via the oxidative 
      stress-responsive NF-kappaB pathway, highlighting its potential as a useful 
      therapeutic agent for asthma management.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Hwang, Yong Pil
AU  - Hwang YP
AD  - Department of Pharmaceutical Engineering, International University of Korea, 
      Jinju, Republic of Korea.
FAU - Jin, Sun Woo
AU  - Jin SW
AD  - Department of Toxicology, College of Pharmacy, Chungnam National University, 
      Daejeon, Republic of Korea.
FAU - Choi, Jae Ho
AU  - Choi JH
AD  - Department of Toxicology, College of Pharmacy, Chungnam National University, 
      Daejeon, Republic of Korea.
FAU - Choi, Chul Yung
AU  - Choi CY
AD  - Jeollanamdo Institute of Natural Resources Research, Jeollanamdo, Republic of 
      Korea.
FAU - Kim, Hyung Gyun
AU  - Kim HG
AD  - Department of Toxicology, College of Pharmacy, Chungnam National University, 
      Daejeon, Republic of Korea.
FAU - Kim, Se Jong
AU  - Kim SJ
AD  - Department of Toxicology, College of Pharmacy, Chungnam National University, 
      Daejeon, Republic of Korea.
FAU - Kim, Yongan
AU  - Kim Y
AD  - Department of Toxicology, College of Pharmacy, Chungnam National University, 
      Daejeon, Republic of Korea.
FAU - Lee, Kyung Jin
AU  - Lee KJ
AD  - Department of Convergence Medicine, Asan Institute for Life Sciences, University 
      of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
FAU - Chung, Young Chul
AU  - Chung YC
AD  - Department of Food and Medicine, College of Public Health and Natural Science, 
      International University of Korea, Jinju, Republic of Korea.
FAU - Jeong, Hye Gwang
AU  - Jeong HG
AD  - Department of Toxicology, College of Pharmacy, Chungnam National University, 
      Daejeon, Republic of Korea. Electronic address: hgjeong@cnu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20161129
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Glutamates)
RN  - 8021PR16QO (theanine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Anti-Asthmatic Agents/*pharmacology
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Asthma/chemically induced/*drug therapy/immunology
MH  - Blotting, Western
MH  - Cytokines/metabolism
MH  - Female
MH  - Glutamates/*pharmacology
MH  - Inflammation/chemically induced/*drug therapy/immunology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Ovalbumin/*toxicity
MH  - Respiratory System/*drug effects
OTO - NOTNLM
OT  - Airway inflammation
OT  - Cytokine
OT  - L-theanine
OT  - NF-kappaB
OT  - Ovalbumin
EDAT- 2016/12/03 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/07/20 00:00 [received]
PHST- 2016/11/22 00:00 [revised]
PHST- 2016/11/25 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - S0278-6915(16)30450-1 [pii]
AID - 10.1016/j.fct.2016.11.032 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2017 Jan;99:162-169. doi: 10.1016/j.fct.2016.11.032. Epub 2016 
      Nov 29.