PMID- 27908749
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20220408
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 320
DP  - 2017 Mar 1
TI  - A new role for GABAergic transmission in the control of male rat sexual behavior 
      expression.
PG  - 21-29
LID - S0166-4328(16)30849-X [pii]
LID - 10.1016/j.bbr.2016.11.041 [doi]
AB  - GABAergic transmission in the ventral tegmental area (VTA) exerts a tonic 
      inhibitory influence on mesolimbic dopaminergic neurons' activity. Blockade of 
      VTA GABA(A) receptors increases dopamine release in the nucleus accumbens (NAcc). 
      Increases in NAcc dopamine levels typically accompany sexual behavior display. 
      Copulation to satiety is characterized by the instatement of a long lasting (72h) 
      sexual behavior inhibition and the mesolimbic system appears to be involved in 
      this phenomenon. GABAergic transmission in the VTA might play a role in the 
      maintenance of this long lasting sexual inhibitory state. To test this 
      hypothesis, in the present work we investigated the effect of GABA(A) receptor 
      blockade in sexually exhausted males 24h after copulation to satiety, once the 
      sexual inhibitory state is established, and compared it with its effect in 
      sexually experienced rats. Results showed that low doses of systemically 
      administered bicuculline induced sexual behavior expression in sexually exhausted 
      rats, but lacked an effect on copulation of sexually experienced animals. 
      Intra-VTA bilateral infusion of bicuculline did not modify sexual behavior of 
      sexually experienced rats, but induced sexual behavior expression in all the 
      sexually exhausted males. Hence, GABA plays a role in the control of sexual 
      behavior expression at the VTA. The role played by GABAergic transmission in male 
      sexual behavior expression of animals with distinct sexual behavior conditions is 
      discussed.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Rodriguez-Manzo, Gabriela
AU  - Rodriguez-Manzo G
AD  - Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados 
      (Cinvestav-Sede Sur), Calzada de los Tenorios 235, Col. Granjas Coapa, Delegacion 
      Tlalpan, Mexico D.F., 14330, Mexico. Electronic address: grodrigu@cinvestav.mx.
FAU - Canseco-Alba, Ana
AU  - Canseco-Alba A
AD  - Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados 
      (Cinvestav-Sede Sur), Calzada de los Tenorios 235, Col. Granjas Coapa, Delegacion 
      Tlalpan, Mexico D.F., 14330, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161128
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (GABA-A Receptor Antagonists)
RN  - 40709-69-1 (bicuculline methiodide)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Bicuculline/analogs & derivatives/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - GABA-A Receptor Antagonists/pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/drug effects
MH  - Sexual Behavior, Animal/drug effects/*physiology
MH  - Statistics, Nonparametric
MH  - Synaptic Transmission/drug effects/*physiology
MH  - Ventral Tegmental Area/drug effects/physiology
MH  - gamma-Aminobutyric Acid/*metabolism
OTO - NOTNLM
OT  - Bicuculline
OT  - GABA(A) receptors
OT  - Male sexual behavior
OT  - Mesolimbic system
OT  - Sexual inhibition
OT  - Sexual responding
OT  - Sexual satiety
OT  - VTA
EDAT- 2016/12/03 06:00
MHDA- 2017/12/27 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/10/16 00:00 [received]
PHST- 2016/11/21 00:00 [revised]
PHST- 2016/11/25 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - S0166-4328(16)30849-X [pii]
AID - 10.1016/j.bbr.2016.11.041 [doi]
PST - ppublish
SO  - Behav Brain Res. 2017 Mar 1;320:21-29. doi: 10.1016/j.bbr.2016.11.041. Epub 2016 
      Nov 28.