PMID- 27909648
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240326
IS  - 2196-3029 (Print)
IS  - 2196-3029 (Electronic)
VI  - 3
IP  - 4
DP  - 2016
TI  - Fcgamma Receptors in Solid Organ Transplantation.
PG  - 284-293
AB  - In the current era, one of the major factors limiting graft survival is chronic 
      antibody-mediated rejection (ABMR), whilst patient survival is impacted by the 
      effects of immunosuppression on susceptibility to infection, malignancy and 
      atherosclerosis. IgG antibodies play a role in all of these processes, and many 
      of their cellular effects are mediated by Fc gamma receptors (FcgammaRs). These 
      surface receptors are expressed by most immune cells, including B cells, natural 
      killer cells, dendritic cells and macrophages. Genetic variation in FCGR genes is 
      likely to affect susceptibility to ABMR and to modulate the physiological 
      functions of IgG. In this review, we discuss the potential role played by FcgammaRs 
      in determining outcomes in solid organ transplantation, and how genetic 
      polymorphisms in these receptors may contribute to variations in transplant 
      outcome.
FAU - Castro-Dopico, Tomas
AU  - Castro-Dopico T
AD  - Molecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular 
      Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical 
      Campus, Cambridge, CB2 0QH UK.
FAU - Clatworthy, Menna R
AU  - Clatworthy MR
AD  - Molecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular 
      Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical 
      Campus, Cambridge, CB2 0QH UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20161003
PL  - Switzerland
TA  - Curr Transplant Rep
JT  - Current transplantation reports
JID - 101624626
PMC - PMC5107199
OTO - NOTNLM
OT  - Antibodies
OT  - Antibody-mediated rejection
OT  - Fcgamma receptors
OT  - IgG
OT  - Infection
OT  - Single nucleotide polymorphisms
COIS- Menna Clatworthy and Tomas Castro-Dopico declare no conflict of interest. Human 
      and Animal Rights and Informed Consent This article does not contain any studies 
      with human or animal subjects performed by any of the authors.
EDAT- 2016/12/03 06:00
MHDA- 2016/12/03 06:01
PMCR- 2016/10/03
CRDT- 2016/12/03 06:00
PHST- 2016/12/03 06:00 [entrez]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2016/12/03 06:01 [medline]
PHST- 2016/10/03 00:00 [pmc-release]
AID - 116 [pii]
AID - 10.1007/s40472-016-0116-7 [doi]
PST - ppublish
SO  - Curr Transplant Rep. 2016;3(4):284-293. doi: 10.1007/s40472-016-0116-7. Epub 2016 
      Oct 3.