PMID- 27909742
OWN - NLM
STAT- MEDLINE
DCOM- 20170221
LR  - 20220408
IS  - 1432-1912 (Electronic)
IS  - 0028-1298 (Linking)
VI  - 390
IP  - 2
DP  - 2017 Feb
TI  - The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 
      antagonist, against estradiol-induced nonbacterial inflammation in the rat 
      prostate.
PG  - 197-205
LID - 10.1007/s00210-016-1325-4 [doi]
AB  - There is no standard treatment of chronic nonbacterial prostatitis in humans. The 
      current study was aimed to investigate the effect of montelukast, an antagonist 
      of cysteinyl leukotriene receptor-1, against estrogen-induced, nonbacterial 
      lateral lobe-specific prostate inflammation in rats. Male Wistar rats were 
      randomized into five groups of six rats, including sham controls (group 1) and 
      castrated rats (group 2), whereas nonbacterial prostatitis (NBP) was induced in 
      groups 3-5 by castration followed by a daily subcutaneous injection of estradiol 
      (0.25 mg/kg body weight) for 30 days. The rats were left otherwise untreated 
      (group 3) or received a daily oral administration of montelukast (1 and 10 mg/kg 
      body weight for groups 4 and 5, respectively) from the 17th day after castration 
      for two consecutive weeks. Compared with sham controls, induction of NBP led to a 
      significant increase in serum leukotriene B(4) (LTB4), tumor necrosis factor 
      alpha (TNF-alpha), and interleukin 6 (IL-6) levels, along with a significant 
      upregulation in the transcript level of proinflammatory molecules (nuclear factor 
      kappa beta [NF-kappabeta] and inducible nitric oxide synthase [iNOS]), chemokines 
      (monocyte chemoattractant protein-1 [MCP-1] and eotaxin), and E-selectin in the 
      lateral prostate. Histological examination revealed intense inflammation in the 
      prostate with leukocyte infiltration and acinar degeneration following estradiol 
      treatment of castrated rats. Montelukast significantly suppressed the increase in 
      serum and prostate proinflammatory mediators/chemokines expression and abolished 
      the histologically inflammatory changes in the lateral prostate. These findings 
      indicate that montelukast inhibits estradiol-induced NBP in a rat model through 
      anti-inflammatory mechanisms, suggesting its future beneficial effect for the 
      treatment of clinical chronic NBP.
FAU - Said, Mahmoud M
AU  - Said MM
AD  - Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, 
      Egypt. mahmoudmsaid@sci.asu.edu.eg.
FAU - Bosland, Maarten C
AU  - Bosland MC
AD  - Department of Pathology, College of Medicine, University of Illinois at Chicago, 
      Chicago, IL, USA.
LA  - eng
PT  - Journal Article
DEP - 20161201
PL  - Germany
TA  - Naunyn Schmiedebergs Arch Pharmacol
JT  - Naunyn-Schmiedeberg's archives of pharmacology
JID - 0326264
RN  - 0 (Acetates)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cyclopropanes)
RN  - 0 (E-Selectin)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Leukotriene Antagonists)
RN  - 0 (NF-kappa B)
RN  - 0 (Quinolines)
RN  - 0 (Receptors, Leukotriene)
RN  - 0 (Sulfides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nos2 protein, rat)
RN  - LRF7RW46ID (leukotriene D4 receptor)
RN  - MHM278SD3E (montelukast)
SB  - IM
MH  - Acetates/*pharmacology
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Chemokine CCL2/genetics/metabolism
MH  - Cyclopropanes
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - E-Selectin/genetics/metabolism
MH  - *Estradiol
MH  - Gene Expression Regulation
MH  - Inflammation Mediators/blood
MH  - Interleukin-6/blood
MH  - Leukotriene Antagonists/*pharmacology
MH  - Leukotriene B4/blood
MH  - Male
MH  - NF-kappa B/genetics/metabolism
MH  - Nitric Oxide Synthase Type II/genetics/metabolism
MH  - Orchiectomy
MH  - Prostate/*drug effects/metabolism/pathology
MH  - Prostatitis/chemically induced/genetics/metabolism/pathology/*prevention & 
      control
MH  - Quinolines/*pharmacology
MH  - Rats, Wistar
MH  - Receptors, Leukotriene/*drug effects/metabolism
MH  - Sulfides
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Chemokines
OT  - Cytokines
OT  - Leukotrienes
OT  - Montelukast
OT  - Nonbacterial prostatitis
EDAT- 2016/12/03 06:00
MHDA- 2017/02/22 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/09/27 00:00 [received]
PHST- 2016/11/21 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/02/22 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - 10.1007/s00210-016-1325-4 [pii]
AID - 10.1007/s00210-016-1325-4 [doi]
PST - ppublish
SO  - Naunyn Schmiedebergs Arch Pharmacol. 2017 Feb;390(2):197-205. doi: 
      10.1007/s00210-016-1325-4. Epub 2016 Dec 1.