PMID- 27909988
OWN - NLM
STAT- MEDLINE
DCOM- 20170711
LR  - 20231117
IS  - 1866-3370 (Print)
IS  - 1866-3370 (Linking)
VI  - 32
DP  - 2017
TI  - Predicting the Abuse Liability of Entactogen-Class, New and Emerging Psychoactive 
      Substances via Preclinical Models of Drug Self-administration.
PG  - 145-164
LID - 10.1007/7854_2016_54 [doi]
AB  - Animal models of drug self-administration are currently the gold standard for 
      making predictions regarding the relative likelihood that a recreational drug 
      substance will lead to continued use and addiction. Such models have been found 
      to have high predictive accuracy and discriminative validity for a number of drug 
      classes including ethanol, nicotine, opioids, and psychostimulants such as 
      cocaine and methamphetamine. Members of the entactogen class of psychostimulants 
      (drugs that produce an "open mind state" including feelings of interpersonal 
      closeness, intimacy and empathy) have been less frequently studied in 
      self-administration models. The prototypical entactogen 
      3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") supports self-administration 
      but not with the same consistency nor with the same efficacy as structurally 
      related drugs amphetamine or methamphetamine. Consistent with these observations, 
      MDMA use is more episodic in the majority of those who use it frequently. 
      Nevertheless, substantial numbers of MDMA users will meet the criteria for 
      substance dependence at some point in their use history. This review examines the 
      currently available evidence from rodent self-administration studies of MDMA and 
      two of the new and emerging psychoactive substances (NPS) that produce entactogen 
      type neuropharmacological responses - mephedrone (4-methylmethcathinone; 4MMC; 
      "meow meow") and methylone (3,4-methylenedioxymethcathinone). Overall, the 
      current evidence predicts that these NPS entactogens have enhanced abuse 
      liability compared with MDMA.
FAU - Aarde, Shawn M
AU  - Aarde SM
AD  - Committee on the Neurobiology of Addictive Disorders Mailcode SP30-2400, The 
      Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, 
      USA.
FAU - Taffe, Michael A
AU  - Taffe MA
AD  - Committee on the Neurobiology of Addictive Disorders Mailcode SP30-2400, The 
      Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, 
      USA. mtaffe@scripps.edu.
LA  - eng
GR  - R01 DA024105/DA/NIDA NIH HHS/United States
GR  - R01 DA024705/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Germany
TA  - Curr Top Behav Neurosci
JT  - Current topics in behavioral neurosciences
JID - 101535383
RN  - 0 (Psychotropic Drugs)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8BA8T27317 (mephedrone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - L4I4B1R01F (methylone)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Methamphetamine/*analogs & derivatives/pharmacology
MH  - Models, Animal
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Psychotropic Drugs/*pharmacology
MH  - Rats
MH  - *Self Administration
MH  - *Substance-Related Disorders
OTO - NOTNLM
OT  - Addiction
OT  - Drug abuse
OT  - Empathogen
OT  - Entactogen
OT  - MDMA
OT  - Mephedrone
OT  - Methylone
OT  - Self-administration
EDAT- 2016/12/03 06:00
MHDA- 2017/07/14 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - 10.1007/7854_2016_54 [doi]
PST - ppublish
SO  - Curr Top Behav Neurosci. 2017;32:145-164. doi: 10.1007/7854_2016_54.