PMID- 27910184
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20171116
IS  - 1399-3062 (Electronic)
IS  - 1398-2273 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Feb
TI  - Clinical significance of pre-transplant circulating CD3(+) CD4(+) CD161(+) cell 
      frequency on the occurrence of neutropenic infections after allogeneic stem cell 
      transplantation.
LID - 10.1111/tid.12643 [doi]
AB  - BACKGROUND: Few studies have been performed to identify factors that are 
      associated with an increased risk of infections during the neutropenic period in 
      patients undergoing allogeneic stem cell transplantation (allo-SCT). The aim of 
      this study was to identify the host immune cells responsible for infections 
      before engraftment. METHODS: A total of 282 patients who underwent allo-SCT were 
      enrolled. Peripheral blood samples were collected before conditioning therapy. 
      Expression of CD161-expressing T cells, natural killer cells, and immature 
      myeloid cells was analyzed by flow cytometry. Microbially and clinically defined 
      infections and fevers of unknown origin as proposed by the Immunocompromised Host 
      Society were included in this study. RESULTS: The median age was 45 years (range, 
      16-68 years). Patients had various hematologic disorders and were transplanted 
      from human leukocyte antigen (HLA)-matched siblings, unrelated donors, and 
      familial HLA-mismatched donors. In univariate analysis, younger age and a 
      familial HLA-mismatched donor were risk factors for the occurrence of infections. 
      After adjusting for potential variables in univariate analysis, multivariate 
      analyses revealed that a lower frequency of CD3(+) CD4(+) CD161(+) cells was 
      significantly associated with the occurrence of neutropenic infections. An age of 
      35 years or younger and allografting from familial HLA-mismatched donors showed a 
      trend toward higher infection rates. CONCLUSION: Our data indicated that a lower 
      frequency of CD3(+) CD4(+) CD161(+) T cells in peripheral blood before 
      conditioning therapy was associated with a higher incidence of infection during 
      the neutropenic period. These results suggest that recipient innate T cells with 
      expression of C-type lectin CD161 can guard against infections before 
      engraftment.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Kim, Tae Woo
AU  - Kim TW
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Lee, Sung-Eun
AU  - Lee SE
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Lim, Ji-Young
AU  - Lim JY
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Ryu, Da-Bin
AU  - Ryu DB
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Jeon, Young-Woo
AU  - Jeon YW
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Yoon, Jae-Ho
AU  - Yoon JH
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Cho, Byung-Sik
AU  - Cho BS
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
AD  - Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, 
      Korea.
FAU - Eom, Ki-Seong
AU  - Eom KS
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
AD  - Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, 
      Korea.
FAU - Kim, Yoo-Jin
AU  - Kim YJ
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
AD  - Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, 
      Korea.
FAU - Kim, Hee-Je
AU  - Kim HJ
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
AD  - Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, 
      Korea.
FAU - Lee, Seok
AU  - Lee S
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
AD  - Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, 
      Korea.
FAU - Cho, Seok-Goo
AU  - Cho SG
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Kim, Dong-Wook
AU  - Kim DW
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
AD  - Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, 
      Korea.
FAU - Lee, Jong Wook
AU  - Lee JW
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Min, Woo-Sung
AU  - Min WS
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Min, Chang-Ki
AU  - Min CK
AD  - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
AD  - Catholic Leukemia Research Institute, The Catholic University of Korea, Seoul, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20170110
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
RN  - 0 (CD3 Complex)
RN  - 0 (Myeloablative Agonists)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily B)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - CD3 Complex/metabolism
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Female
MH  - Fever of Unknown Origin/blood/epidemiology/*immunology
MH  - Flow Cytometry
MH  - Graft vs Host Disease/prevention & control
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - *Immunity, Cellular
MH  - Immunocompromised Host/*immunology
MH  - Killer Cells, Natural/metabolism
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Myeloablative Agonists/adverse effects/therapeutic use
MH  - Myeloid Cells/metabolism
MH  - NK Cell Lectin-Like Receptor Subfamily B/metabolism
MH  - Neutropenia/blood/epidemiology/*immunology
MH  - T-Lymphocytes/*immunology/metabolism
MH  - Transplantation Conditioning/*adverse effects
MH  - Transplantation, Homologous/adverse effects
MH  - Young Adult
OTO - NOTNLM
OT  - CD3+CD4+CD161+ T cells
OT  - allogeneic stem cell transplantation
OT  - cytomegalovirus
OT  - graft-versus-host disease
OT  - neutropenic infection
EDAT- 2016/12/03 06:00
MHDA- 2017/08/08 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/05/29 00:00 [received]
PHST- 2016/08/13 00:00 [revised]
PHST- 2016/09/04 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - 10.1111/tid.12643 [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2017 Feb;19(1). doi: 10.1111/tid.12643. Epub 2017 Jan 10.