PMID- 27910249
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 89
IP  - 1
DP  - 2017 Jan
TI  - The HLA-A, -B and -DRB1 polymorphism in a large dataset of South Brazil bone 
      marrow donors from Rio Grande do Sul.
PG  - 29-38
LID - 10.1111/tan.12933 [doi]
AB  - Human leukocyte antigen (HLA) genes are very informative in population genetics 
      studies and their variability has been widely used to reconstruct the history of 
      geographic and/or demographic expansions of human populations. The 
      characterization of HLA diversity at the population level is also fundamental in 
      clinical studies, particularly for bone marrow transplantation programs. In this 
      study, we investigated the HLA molecular variation in Rio Grande do Sul, South 
      Brazil, in order to identify possible regional differences across this state. 
      More than 97,000 bone marrow donors were typed at the HLA- A, -B and -DRB1 loci 
      and analyzed by considering two kinds of subdivisions based on both 
      self-identified ethnicity and place of residence: (a) the official geographic 
      subdivision defined by the Brazilian Institute of Geography and Statistics and 
      (b) known information about the colonization history of the state. HLA allele and 
      haplotype frequencies were estimated and compared among the defined subgroups. 
      The results indicate a lack of correlation between genetic variation and 
      geography and thus no clear HLA genetic structure based on geographic criteria. 
      On the other hand, major differences were observed regarding ethnicity. In 
      addition, local populations from Rio Grande do Sul were found to be genetically 
      similar to their corresponding parental European populations from Germany, Italy 
      and Portugal, as documented by historical data. Overall, this study provides a 
      thorough characterization of the HLA genetic variation in Rio Grande do Sul and a 
      better understanding of its demographic history, being most useful for the 
      development of more efficient strategies in bone marrow donors' recruitment.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Boquett, J A
AU  - Boquett JA
AUID- ORCID: 0000-0002-6437-789X
AD  - Instituto Nacional de Genetica Medica Populacional (iNaGeMP), Departamento de 
      Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Nunes, J M
AU  - Nunes JM
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution - Anthropology Unit, University of Geneva, Geneva, Switzerland.
AD  - Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, 
      Geneva, Switzerland.
FAU - Buhler, S
AU  - Buhler S
AUID- ORCID: 0000-0001-6675-5287
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution - Anthropology Unit, University of Geneva, Geneva, Switzerland.
AD  - Transplantation Immunology Unit and National Reference Laboratory for 
      Histocompatibility, Department of Genetic and Laboratory Medicine, Geneva 
      University Hospitals, Geneva, Switzerland.
FAU - de Oliveira, M Z
AU  - de Oliveira MZ
AD  - Instituto Nacional de Genetica Medica Populacional (iNaGeMP), Departamento de 
      Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
AD  - Advanced Visualization Laboratory (VIZLab), Universidade do Vale dos Sinos, Sao 
      Leopoldo, Brazil.
FAU - Jobim, L F
AU  - Jobim LF
AD  - Department of Immunology, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      Brazil.
FAU - Jobim, M
AU  - Jobim M
AD  - Department of Immunology, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      Brazil.
FAU - Fagundes, N J R
AU  - Fagundes NJ
AD  - Instituto Nacional de Genetica Medica Populacional (iNaGeMP), Departamento de 
      Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Schuler-Faccini, L
AU  - Schuler-Faccini L
AD  - Instituto Nacional de Genetica Medica Populacional (iNaGeMP), Departamento de 
      Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Sanchez-Mazas, A
AU  - Sanchez-Mazas A
AD  - Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics 
      and Evolution - Anthropology Unit, University of Geneva, Geneva, Switzerland.
AD  - Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, 
      Geneva, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20161202
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
OTO - NOTNLM
OT  - HLA
OT  - bone marrow donors
OT  - genetic diversity
OT  - population genetics
EDAT- 2016/12/03 06:00
MHDA- 2016/12/03 06:01
CRDT- 2016/12/03 06:00
PHST- 2016/07/22 00:00 [received]
PHST- 2016/10/12 00:00 [revised]
PHST- 2016/10/26 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2016/12/03 06:01 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - 10.1111/tan.12933 [doi]
PST - ppublish
SO  - HLA. 2017 Jan;89(1):29-38. doi: 10.1111/tan.12933. Epub 2016 Dec 2.