PMID- 27910718
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20180118
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 33
IP  - 4
DP  - 2017 Apr
TI  - Substituting poly- and mono-unsaturated fat for dietary carbohydrate reduces 
      hyperinsulinemia in women with polycystic ovary syndrome.
PG  - 324-327
LID - 10.1080/09513590.2016.1259407 [doi]
AB  - OBJECTIVE: Hyperinsulinemia is a prevalent feature of polycystic ovary syndrome 
      (PCOS), contributing to metabolic and reproductive manifestations of the 
      syndrome. Weight loss reduces hyperinsulinemia but weight regain is the norm, 
      thus preventing long-term benefits. In the absence of weight loss, replacement of 
      dietary carbohydrate (CHO) with mono/polyunsaturated fat reduces ambient insulin 
      concentrations in non-PCOS subjects. The current study evaluated whether this 
      dietary intervention could ameliorate hyperinsulinemia in women with PCOS. 
      DESIGN/SETTING/PATIENTS: Obese women with PCOS (BMI 39 +/- 7 kg/m(2)) and insulin 
      resistance completed a crossover study (Stanford University Clinical Research 
      Center) comparing two isocaloric diets, prepared by research dietitians, 
      containing 60% CHO/25% fat versus 40% CHO/45% fat (both 15% protein and </=7% 
      saturated fat). After 3 weeks on each diet, daylong glucose, insulin, and fasting 
      lipid/lipoproteins were measured. RESULTS: Daylong glucose did not differ 
      according to diet. Daylong insulin concentrations were substantially (30%) and 
      significantly lower on the low CHO/higher fat diet. Beneficial changes in lipid 
      profile were also observed. CONCLUSIONS: Replacement of dietary CHO with 
      mono/polyunsaturated fat yields clinically important reductions in daylong 
      insulin concentrations, without adversely affecting lipid profile in obese, 
      insulin-resistant women with PCOS. This simple and safe dietary intervention may 
      constitute an important treatment for PCOS. ClinicalTrials.gov Identifier: 
      NCT00186459.
FAU - Perelman, Dalia
AU  - Perelman D
AD  - a Division of Endocrinology , Stanford University School of Medicine , Stanford , 
      CA , USA.
FAU - Coghlan, Nicole
AU  - Coghlan N
AD  - a Division of Endocrinology , Stanford University School of Medicine , Stanford , 
      CA , USA.
FAU - Lamendola, Cindy
AU  - Lamendola C
AD  - a Division of Endocrinology , Stanford University School of Medicine , Stanford , 
      CA , USA.
FAU - Carter, Susan
AU  - Carter S
AD  - a Division of Endocrinology , Stanford University School of Medicine , Stanford , 
      CA , USA.
FAU - Abbasi, Fahim
AU  - Abbasi F
AD  - a Division of Endocrinology , Stanford University School of Medicine , Stanford , 
      CA , USA.
FAU - McLaughlin, Tracey
AU  - McLaughlin T
AD  - a Division of Endocrinology , Stanford University School of Medicine , Stanford , 
      CA , USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT00186459
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161202
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Fats, Unsaturated/*administration & dosage
MH  - Female
MH  - Humans
MH  - Hyperinsulinism/blood/*diet therapy
MH  - Insulin/*blood
MH  - Insulin Resistance/*physiology
MH  - Lipids/blood
MH  - Obesity/blood
MH  - Polycystic Ovary Syndrome/blood/*diet therapy
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Carbohydrate
OT  - PCOS
OT  - diet
OT  - insulin
OT  - insulin-resistant
OT  - obesity
EDAT- 2016/12/03 06:00
MHDA- 2017/09/28 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - 10.1080/09513590.2016.1259407 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2017 Apr;33(4):324-327. doi: 10.1080/09513590.2016.1259407. 
      Epub 2016 Dec 2.