PMID- 27911049 OWN - NLM STAT- MEDLINE DCOM- 20170629 LR - 20221207 IS - 1930-739X (Electronic) IS - 1930-7381 (Print) IS - 1930-7381 (Linking) VI - 25 IP - 1 DP - 2017 Jan TI - Family PArtners in Lifestyle Support (PALS): Family-based weight loss for African American adults with type 2 diabetes. PG - 45-55 LID - 10.1002/oby.21700 [doi] AB - OBJECTIVE: To develop and test a family-centered behavioral weight loss intervention for African American adults with type 2 diabetes. METHODS: In this randomized trial, dyads consisting of an African American adult with overweight or obesity and type 2 diabetes (index participant) paired with a family partner with overweight or obesity but not diagnosed with diabetes were assigned in a 2:1 ratio to a 20-week special intervention (SI) or delayed intervention (DI) control group. The primary outcome was weight loss among index participants at the 20-week follow-up. RESULTS: One hundred eight participants (54 dyads-36 (SI) and 18 (DI) dyads) were enrolled: 81% females; mean age, 51 years; mean weight,103 kg; and mean BMI, 37 kg/m(2) . At post-intervention, 96 participants (89%) returned for follow-up measures. Among index participants, mean difference in weight loss between groups was -5.0 kg, P <0.0001 (-3.6 kg loss among SI; 1.4 kg gain in DI). SI index participants showed significantly greater improvements in hemoglobin A1c, depressive symptoms, family interactions, and dietary, physical activity, and diabetes self-care behaviors. SI family partners also had significant weight loss (-3.9 kg (SI) vs. -1.0 kg (DI), P = 0.02). CONCLUSIONS: A family-centered, behavioral weight loss intervention led to clinically significant short-term weight loss among family dyads. CI - (c) 2016 The Obesity Society. FAU - Samuel-Hodge, Carmen D AU - Samuel-Hodge CD AD - Department of Nutrition, Gillings School of Global Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Holder-Cooper, Judith C AU - Holder-Cooper JC AD - Department of Psychiatry and Behavioral Science, Duke University, Durham, North Carolina, USA. AD - Department of Community and Family Medicine, Duke University, Durham, North Carolina, USA. FAU - Gizlice, Ziya AU - Gizlice Z AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Davis, Gwendolyn AU - Davis G AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Steele, Sonia P AU - Steele SP AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Keyserling, Thomas C AU - Keyserling TC AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of General Internal Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Kumanyika, Shiriki K AU - Kumanyika SK AD - Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FAU - Brantley, Phillip J AU - Brantley PJ AD - Behavioral Medicine Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Svetkey, Laura P AU - Svetkey LP AD - Department of Medicine, Division of Nephrology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, USA. LA - eng GR - K01 DK080079/DK/NIDDK NIH HHS/United States GR - P30 DK092950/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20161202 PL - United States TA - Obesity (Silver Spring) JT - Obesity (Silver Spring, Md.) JID - 101264860 SB - IM MH - Adult MH - Black or African American/psychology/*statistics & numerical data MH - Diabetes Mellitus, Type 2/complications/*ethnology/*prevention & control MH - *Family Relations MH - Female MH - Humans MH - Life Style MH - Male MH - Middle Aged MH - Obesity/complications/*ethnology/*prevention & control MH - Social Support MH - Weight Loss PMC - PMC5182111 MID - NIHMS821117 COIS- There are no conflicts of interest to declare. EDAT- 2016/12/03 06:00 MHDA- 2017/07/01 06:00 PMCR- 2017/06/02 CRDT- 2016/12/03 06:00 PHST- 2016/02/29 00:00 [received] PHST- 2016/08/30 00:00 [revised] PHST- 2016/09/19 00:00 [accepted] PHST- 2016/12/03 06:00 [pubmed] PHST- 2017/07/01 06:00 [medline] PHST- 2016/12/03 06:00 [entrez] PHST- 2017/06/02 00:00 [pmc-release] AID - 10.1002/oby.21700 [doi] PST - ppublish SO - Obesity (Silver Spring). 2017 Jan;25(1):45-55. doi: 10.1002/oby.21700. Epub 2016 Dec 2.