PMID- 27911281
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20181202
IS  - 1878-6324 (Electronic)
IS  - 1053-8127 (Linking)
VI  - 30
IP  - 3
DP  - 2017
TI  - Polymorphisms in promoter regions of MMP-3 and IL-6 genes are not associated to 
      adolescent idiopathic scoliosis (AIS) gender bias.
PG  - 559-563
LID - 10.3233/BMR-150309 [doi]
AB  - STUDY DESIGN: A retrospective study in Chinese Han people. PURPOSE: To explore 
      whether promoter polymorphisms of matrix metalloproteinases-3 (MMP-3) (rs3025058) 
      and interleukin-6(IL-6) (rs1800795) genes are associated to AIS gender bias. 
      METHODS: A total of 200 patients (100 boys and 100 girls) with AIS and 200 
      healthy age-matched adolescents were recruited from July 2008 to August 2013 in 
      our scoliosis center. All AIS patients had Cobb angles larger than 20 degrees , average 
      43 +/- 3.6 degrees  (range 24-72 degrees ). A case-control study using genotypic technique was 
      conducted to explore whether promoter polymorphisms of MMP-3 and IL-6 were 
      associated to AIS gender bias. In addition, to confirm the association between 
      gene variants of MMP-3 and IL-6 and AIS. Statistical analysis of genotype 
      frequencies between AIS patients and normal controls was performed by X;2 test. 
      RESULTS: The frequency of 5A/5A genotype of MMP-3 gene in patients with AIS was 
      higher than in controls (19% versus 9.5% p= 0.007), in the sub-divided groups 
      depend on gender, no significant difference was found between AIS girls and boys 
      in the frequency of 5A/5A genotype of MMP-3 (20% in girls versus 18% in boys p= 
      0.718). No significant difference was found between AIS and controls in the 
      frequency of G/G genotype of IL-6 (97.5% versus 98%). In the sub-divided groups 
      depend on gender, no significant difference was found between AIS girls and boys 
      in the frequency of G/G genotype of the IL-6 gene (98% in girls versus 97% for 
      boys). CONCLUSIONS: The promoter polymorphism of the MMP-3 gene was confirmed to 
      have an association with AIS and the promoter polymorphism of the IL-6 gene was 
      lack of association with AIS. Besides, both gene variants of MMP-3 and IL-6 were 
      not associated to AIS gender bias.
FAU - Sui, Wenyuan
AU  - Sui W
FAU - Yang, Junlin
AU  - Yang J
FAU - Huang, Zifang
AU  - Huang Z
FAU - Wang, Qifei
AU  - Wang Q
FAU - Fan, Hengwei
AU  - Fan H
FAU - Deng, Yaolong
AU  - Deng Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Back Musculoskelet Rehabil
JT  - Journal of back and musculoskeletal rehabilitation
JID - 9201340
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - China
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-6/*genetics
MH  - Kyphosis
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Retrospective Studies
MH  - Scoliosis/*genetics
MH  - Sex Characteristics
MH  - Young Adult
OTO - NOTNLM
OT  - Adolescent idiopathic scoliosis
OT  - gender
OT  - interleukin-6
OT  - matrix metalloproteinases-3
EDAT- 2016/12/03 06:00
MHDA- 2018/01/03 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - BMR150309 [pii]
AID - 10.3233/BMR-150309 [doi]
PST - ppublish
SO  - J Back Musculoskelet Rehabil. 2017;30(3):559-563. doi: 10.3233/BMR-150309.