PMID- 27911986
OWN - NLM
STAT- MEDLINE
DCOM- 20171011
LR  - 20180319
IS  - 1467-789X (Electronic)
IS  - 1467-7881 (Linking)
VI  - 18
IP  - 2
DP  - 2017 Feb
TI  - Persistent organic pollutants in adipose tissue should be considered in obesity 
      research.
PG  - 129-139
LID - 10.1111/obr.12481 [doi]
AB  - Although low doses of persistent organic pollutants (POPs), strong lipophilic 
      chemicals with long half-lives, have been linked to various endocrine, immune, 
      nervous and reproductive system diseases, few obesity studies have considered 
      adipose tissue as an important POPs exposure source. Because the toxicodynamics 
      of POPs relate directly to the dynamics of adiposity, POPs might explain puzzling 
      findings in obesity research. In two people exposed to the same amounts of 
      environmental POPs, the one having more adipose tissue may be advantaged because 
      POPs storage in adipose tissue can reduce burden on other critical organs. 
      Therefore, adipose tissue can play a protective role against the POPs effects. 
      However, two situations increase the POPs release from adipose tissue into the 
      circulation, thereby increasing the risk that they will reach critical organs: 
      (i) weight loss and (ii) insulin resistance. In contrast, weight gain reduces 
      this possibility. Therefore, avoiding harmful health effects of POPs may mostly 
      contradict conventional judgments about obesity and weight change. These 
      contradictory situations can explain the obesity paradox, the adverse effects of 
      intensive intentional weight loss and the protective effects of obesity against 
      dementia. Future studies should consider that adipose tissue is widely 
      contaminated with POPs in modern society.
CI  - (c) 2016 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf 
      of World Obesity Federation.
FAU - Lee, Y-M
AU  - Lee YM
AUID- ORCID: 0000-0003-3206-7894
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
FAU - Kim, K-S
AU  - Kim KS
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
FAU - Jacobs, D R Jr
AU  - Jacobs DR Jr
AD  - Division of Epidemiology and Community Health, School of Public Health, 
      University of Minnesota, Minneapolis, MN, USA.
FAU - Lee, D-H
AU  - Lee DH
AD  - Department of Preventative Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Korea.
AD  - BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, 
      Kyungpook National University, Daegu, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161202
PL  - England
TA  - Obes Rev
JT  - Obesity reviews : an official journal of the International Association for the 
      Study of Obesity
JID - 100897395
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adiposity/*drug effects
MH  - Body Weight
MH  - Environmental Pollutants/*adverse effects/analysis
MH  - Humans
MH  - Insulin Resistance
MH  - Obesity/chemically induced/*epidemiology
MH  - Risk Factors
OTO - NOTNLM
OT  - Dementia
OT  - obesity paradox
OT  - persistent organic pollutants
OT  - weight loss
EDAT- 2016/12/03 06:00
MHDA- 2017/10/12 06:00
CRDT- 2016/12/03 06:00
PHST- 2016/08/17 00:00 [received]
PHST- 2016/09/23 00:00 [revised]
PHST- 2016/09/28 00:00 [accepted]
PHST- 2016/12/03 06:00 [pubmed]
PHST- 2017/10/12 06:00 [medline]
PHST- 2016/12/03 06:00 [entrez]
AID - 10.1111/obr.12481 [doi]
PST - ppublish
SO  - Obes Rev. 2017 Feb;18(2):129-139. doi: 10.1111/obr.12481. Epub 2016 Dec 2.