PMID- 27913009 OWN - NLM STAT- MEDLINE DCOM- 20171127 LR - 20171128 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 231 DP - 2017 Mar 15 TI - Quantitative changes in late gadolinium enhancement at cardiac magnetic resonance in the early phase of acute myocarditis. PG - 216-221 LID - S0167-5273(16)32250-1 [pii] LID - 10.1016/j.ijcard.2016.11.282 [doi] AB - BACKGROUND: The presence of late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) has diagnostic and prognostic value in patients with acute myocarditis (AM). Aim of our study was to quantify the changes in LGE extension (LGE%) early after AM and evaluate its relations with biventricular function and morphology. METHODS: We investigated 76 consecutive patients with AM (acute onset of chest pain/heart failure/ventricular arrhythmias not explained by other causes, and raised troponin) that met CMR criteria based on myocardial oedema at T2-weighted images and LGE on post-contrast images at median time of 6days from onset of symptoms. We quantified LGE% at baseline and after 148days in 49 patients. RESULTS: Median left ventricular (LV)-ejection fraction (EF) was 64% (interquartile range [Q1-Q3]: 56-67%), and LGE% 9.4% (Q1-Q3: 7.5-13.2%). LGE% was correlated with LV end-systolic volume index (LV-ESVi; r=+0.34; p=0.003). LGE% was inversely correlated with LV-EF (r=-0.31; p=0.009) and time to CMR scan (r=-0.25; p=0.028). In the 49 patients with a second CMR scan, despite no significant variations in LV-EF, a significant decrease of LGE% was observed (p<0.0001) with a relative reduction of 42% compared with baseline. Patients showing increased LV-ESVi at follow up had a lower decrease of LGE% (p=0.038). CONCLUSIONS: In the acute phase of AM the LGE extension is a dynamic process that reflects impairment of LV function and is time dependent. LGE% appears one of the CMR parameters with the largest relative variations in the first months after AM. CI - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved. FAU - Ammirati, Enrico AU - Ammirati E AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy. Electronic address: enrico.ammirati@ospedaleniguarda.it. FAU - Moroni, Francesco AU - Moroni F AD - Cardiothoracic Department, San Raffaele Hospital and Vita Salute University, Milano, Italy. FAU - Sormani, Paola AU - Sormani P AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy; Health Science Department, Bicocca University, Milano, Italy. FAU - Peritore, Angelica AU - Peritore A AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy. FAU - Milazzo, Angela AU - Milazzo A AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy. FAU - Quattrocchi, Giuseppina AU - Quattrocchi G AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy. FAU - Cipriani, Manlio AU - Cipriani M AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy. FAU - Oliva, Fabrizio AU - Oliva F AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy. FAU - Giannattasio, Cristina AU - Giannattasio C AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy; Health Science Department, Bicocca University, Milano, Italy. FAU - Frigerio, Maria AU - Frigerio M AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy. FAU - Roghi, Alberto AU - Roghi A AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy. FAU - Camici, Paolo G AU - Camici PG AD - Cardiothoracic Department, San Raffaele Hospital and Vita Salute University, Milano, Italy. Electronic address: camici.paolo@hsr.it. FAU - Pedrotti, Patrizia AU - Pedrotti P AD - "De Gasperis" Cardio Center, Niguarda Hospital, Milan, Italy. LA - eng PT - Journal Article DEP - 20161123 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) RN - AU0V1LM3JT (Gadolinium) SB - IM CIN - Int J Cardiol. 2018 Apr 15;257:227. PMID: 29506700 CIN - Int J Cardiol. 2018 Apr 15;257:341. PMID: 29506727 MH - Acute Disease MH - Adult MH - Contrast Media/pharmacology MH - Disease Progression MH - Female MH - Follow-Up Studies MH - Gadolinium MH - Heart Ventricles/*diagnostic imaging/physiopathology MH - Humans MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Myocarditis/*diagnosis/physiopathology MH - Myocardium/pathology MH - Organometallic Compounds/*pharmacology MH - Prognosis MH - Reproducibility of Results MH - Retrospective Studies MH - Stroke Volume MH - Time Factors MH - Ventricular Function, Left/physiology OTO - NOTNLM OT - Acute myocarditis OT - Cardiac magnetic resonance OT - Fulminant myocarditis OT - Late gadolinium enhancement EDAT- 2016/12/04 06:00 MHDA- 2017/11/29 06:00 CRDT- 2016/12/04 06:00 PHST- 2016/09/13 00:00 [received] PHST- 2016/11/01 00:00 [revised] PHST- 2016/11/15 00:00 [accepted] PHST- 2016/12/04 06:00 [pubmed] PHST- 2017/11/29 06:00 [medline] PHST- 2016/12/04 06:00 [entrez] AID - S0167-5273(16)32250-1 [pii] AID - 10.1016/j.ijcard.2016.11.282 [doi] PST - ppublish SO - Int J Cardiol. 2017 Mar 15;231:216-221. doi: 10.1016/j.ijcard.2016.11.282. Epub 2016 Nov 23.