PMID- 2791344
OWN - NLM
STAT- MEDLINE
DCOM- 19891122
LR  - 20190820
IS  - 0090-1229 (Print)
IS  - 0090-1229 (Linking)
VI  - 53
IP  - 2 Pt 2
DP  - 1989 Nov
TI  - Immunomodulatory effects of intravenous immunoglobulin in severe 
      steroid-dependent asthma.
PG  - S156-63
AB  - Intravenous immunoglobulin (IVIG) has become an accepted mode of therapy in 
      immune diseases with the potential to act as an immune enhancer or 
      immunomodulator. A 14-year-old girl with severe steroid-dependent asthma was 
      enrolled in a trial of high dose intravenous immunoglobulin because of the 
      unremitting nature of her illness and severe steroid side effects. She received 2 
      g/kg of IVIG every month for six months. In the 4 months preceding IVIG therapy 
      she had repeated exacerbations of her asthma. In contrast, during the 6 months of 
      IVIG therapy, she only had one exacerbation of her asthma. Her steroid dose was 
      tapered by 75% and her FEV1 improved by 100%. To detect alterations in immune 
      reactivity, we monitored serial skin tests to an individualized panel of 
      antigens, RAST tests to the same panel, and specific IgG levels. Serial 
      titrations of her prick skin tests showed a 2-3 log increase in threshold for 
      skin reactivity to all five antigens on her panel. In parallel, RAST results to 
      the same antigen panel showed a decrease in specific IgE production. The 
      significant clinical improvement and steroid reduction in this patient appear 
      due, at least in part, to the immunomodulatory effects of high dose IVIG therapy.
FAU - Mazer, B D
AU  - Mazer BD
AD  - Division of Basic Sciences, National Jewish Center for Immunology and Respiratory 
      Medicine, Denver, Colorado 80206.
FAU - Giclas, P C
AU  - Giclas PC
FAU - Gelfand, E W
AU  - Gelfand EW
LA  - eng
GR  - AI 26490/AI/NIAID NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Clin Immunol Immunopathol
JT  - Clinical immunology and immunopathology
JID - 0356637
RN  - 0 (Immunoglobulins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Adolescent
MH  - Asthma/*therapy
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Immunoglobulins/*administration & dosage
MH  - Infusions, Intravenous
MH  - Prednisone/therapeutic use
MH  - Respiratory Function Tests
MH  - Skin Tests
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1016/0090-1229(89)90081-0 [doi]
PST - ppublish
SO  - Clin Immunol Immunopathol. 1989 Nov;53(2 Pt 2):S156-63. doi: 
      10.1016/0090-1229(89)90081-0.