PMID- 27913682
OWN - NLM
STAT- MEDLINE
DCOM- 20170721
LR  - 20171219
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 44
IP  - 6
DP  - 2016 Dec 15
TI  - Translational regulation of mitochondrial biogenesis.
PG  - 1717-1724
AB  - Mitochondria are generated by the expression of genes on both nuclear and 
      mitochondrial genome. Mitochondrial biogenesis is highly plastic in response to 
      cellular energy demand, developmental signals and environmental stimuli. 
      Mechanistic target of rapamycin (mTOR) pathway regulates mitochondrial biogenesis 
      to co-ordinate energy homeostasis with cell growth. The local translation of 
      mitochondrial proteins on the outer membrane facilitates their efficient import 
      and thereby allows prodigious mitochondrial biogenesis during rapid cell growth 
      and proliferation. We postulate that the local translation may also allow cells 
      to promote mitochondrial biogenesis selectively based on the fitness of 
      individual organelle. MDI-Larp complex promotes the biogenesis of healthy 
      mitochondria and thereby is essential for the selective transmission of healthy 
      mitochondria. On the other hand, PTEN-induced putative kinase 1 (PINK1)-Pakin 
      activates protein synthesis on damaged mitochondria to maintain the organelle 
      homeostasis and activity. We also summarize some recent progress on miRNAs' 
      regulation on mitochondrial biogenesis.
CI  - (c) 2016 The Author(s); published by Portland Press Limited on behalf of the 
      Biochemical Society.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
FAU - Xu, Hong
AU  - Xu H
AD  - National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (MicroRNAs)
RN  - 0 (Mitochondrial Proteins)
SB  - IM
MH  - Animals
MH  - *Gene Expression Regulation
MH  - Humans
MH  - MicroRNAs/genetics
MH  - Mitochondria/*genetics/metabolism
MH  - Mitochondrial Membranes/metabolism
MH  - Mitochondrial Proteins/*genetics/metabolism
MH  - Models, Genetic
MH  - *Organelle Biogenesis
MH  - Protein Biosynthesis/*genetics
OTO - NOTNLM
OT  - AKAP
OT  - Larp
OT  - PINK1
OT  - miRNA
OT  - mitochondrial transcription factor A
OT  - mtDNA
EDAT- 2016/12/04 06:00
MHDA- 2017/07/22 06:00
CRDT- 2016/12/04 06:00
PHST- 2016/03/10 00:00 [received]
PHST- 2016/08/30 00:00 [revised]
PHST- 2016/09/02 00:00 [accepted]
PHST- 2016/12/04 06:00 [entrez]
PHST- 2016/12/04 06:00 [pubmed]
PHST- 2017/07/22 06:00 [medline]
AID - BST20160071C [pii]
AID - 10.1042/BST20160071C [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2016 Dec 15;44(6):1717-1724. doi: 10.1042/BST20160071C.