PMID- 27914035
OWN - NLM
STAT- MEDLINE
DCOM- 20171106
LR  - 20200928
IS  - 2629-3277 (Electronic)
IS  - 1550-8943 (Print)
IS  - 2629-3277 (Linking)
VI  - 13
IP  - 2
DP  - 2017 Apr
TI  - Mobilization of Peripheral Blood Stem Cells and Changes in the Concentration of 
      Plasma Factors Influencing their Movement in Patients with Panic Disorder.
PG  - 217-225
LID - 10.1007/s12015-016-9700-6 [doi]
AB  - In this paper we examined whether stem cells and factors responsible for their 
      movement may serve as new biological markers of anxiety disorders. The study was 
      carried out on a group of 30 patients diagnosed with panic disorder (examined 
      before and after treatment), compared to 30 healthy individuals forming the 
      control group. We examined the number of circulating HSCs (hematopoetic stem 
      cells) (Lin-/CD45 +/CD34 +) and HSCs (Lin-/CD45 +/AC133 +), the number of 
      circulating VSELs (very small embryonic-like stem cells) (Lin-/CD45-/CD34 +) and 
      VSELs (Lin-/CD45-/AC133 +), as well as the concentration of complement 
      components: C3a, C5a and C5b-9, SDF-1 (stromal derived factor) and S1P 
      (sphingosine-1-phosphate). Significantly lower levels of HSCs (Lin-/CD45 +/AC133 
      +) have been demonstrated in the patient group compared to the control group both 
      before and after treatment. The level of VSELs (Lin-/CD45-/CD133 +) was 
      significantly lower in the patient group before treatment as compared to the 
      patient group after treatment.The levels of factors responsible for stem cell 
      movement were significantly lower in the patient group compared to the control 
      group before and after treatment. It was concluded that the study of stem cells 
      and factors associated with their movement can be useful in the diagnostics of 
      panic disorder, as well as differentiating between psychotic and anxiety 
      disorders.
FAU - Jablonski, Marcin
AU  - Jablonski M
AD  - Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 
      71-460, Szczecin, Poland.
FAU - Mazur, Jolanta Kucharska
AU  - Mazur JK
AD  - Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 
      71-460, Szczecin, Poland. jola_kucharska@tlen.pl.
FAU - Tarnowski, Maciej
AU  - Tarnowski M
AD  - Department of Physiology, Pomeranian University of Medicine, Szczecin, Poland.
FAU - Dolegowska, Barbara
AU  - Dolegowska B
AD  - Department of Medical Analytics, Pomeranian University of Medicine, Szczecin, 
      Poland.
FAU - Pedziwiatr, Daniel
AU  - Pedziwiatr D
AD  - Department of Physiology, Pomeranian University of Medicine, Szczecin, Poland.
FAU - Kubis, Ewa
AU  - Kubis E
AD  - Department of Physiology, Pomeranian University of Medicine, Szczecin, Poland.
FAU - Budkowska, Marta
AU  - Budkowska M
AD  - Department of Medical Analytics, Pomeranian University of Medicine, Szczecin, 
      Poland.
FAU - Salata, Daria
AU  - Salata D
AD  - Department of Medical Analytics, Pomeranian University of Medicine, Szczecin, 
      Poland.
FAU - Wysiecka, Justyna Pelka
AU  - Wysiecka JP
AD  - Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 
      71-460, Szczecin, Poland.
FAU - Kazimierczak, Arkadiusz
AU  - Kazimierczak A
AD  - Department of Vascular Surgery, Pomeranian University of Medicine, Szczecin, 
      Poland.
FAU - Reginia, Artur
AU  - Reginia A
AD  - Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 
      71-460, Szczecin, Poland.
FAU - Ratajczak, Mariusz Z
AU  - Ratajczak MZ
AD  - Stem Cell Biology Program at the James Graham Brown Cancer Center, University of 
      Louisville, Louisville, KY, 40202, USA.
FAU - Samochowiec, Jerzy
AU  - Samochowiec J
AD  - Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 
      71-460, Szczecin, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
RN  - 0 (AC133 Antigen)
RN  - 0 (Antigens, CD34)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (PROM1 protein, human)
RN  - 9007-36-7 (Complement System Proteins)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - AC133 Antigen/blood
MH  - Adult
MH  - Antigens, CD34/blood
MH  - Anxiety Disorders/blood/pathology
MH  - Cell Count
MH  - *Cell Movement
MH  - Chemokine CXCL12/blood
MH  - Complement System Proteins/metabolism
MH  - Female
MH  - Flow Cytometry
MH  - *Hematopoietic Stem Cell Mobilization
MH  - Humans
MH  - Leukocyte Common Antigens/blood
MH  - Male
MH  - Middle Aged
MH  - Panic Disorder/*blood/pathology
MH  - Peripheral Blood Stem Cells/*metabolism/pathology
MH  - Psychotic Disorders/blood/pathology
MH  - Young Adult
PMC - PMC5380702
OTO - NOTNLM
OT  - Complement components
OT  - Panic disorder
OT  - SDF-1
OT  - Sphingosine - 1 - phosphate
OT  - Stem cells
OT  - VSEL
COIS- All authors do not disclose any actual or potential conflict of interest.
EDAT- 2016/12/04 06:00
MHDA- 2017/11/07 06:00
PMCR- 2016/12/02
CRDT- 2016/12/04 06:00
PHST- 2016/12/04 06:00 [pubmed]
PHST- 2017/11/07 06:00 [medline]
PHST- 2016/12/04 06:00 [entrez]
PHST- 2016/12/02 00:00 [pmc-release]
AID - 10.1007/s12015-016-9700-6 [pii]
AID - 9700 [pii]
AID - 10.1007/s12015-016-9700-6 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2017 Apr;13(2):217-225. doi: 10.1007/s12015-016-9700-6.