PMID- 27916138
OWN - NLM
STAT- MEDLINE
DCOM- 20180103
LR  - 20220330
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 57
DP  - 2016 Dec
TI  - Alcohol exposure differentially effects anti-tumor immunity in females by 
      altering dendritic cell function.
PG  - 1-8
LID - S0741-8329(16)30161-6 [pii]
LID - 10.1016/j.alcohol.2016.10.007 [doi]
AB  - Dendritic cells (DCs) are a critical component of anti-tumor immunity due to 
      their ability to induce a robust immune response to antigen (Ag). Alcohol was 
      previously shown to reduce DC ability to present foreign Ag and promote 
      pro-inflammatory responses in situations of infection and trauma. However the 
      impact of alcohol exposure on generation of an anti-tumor response, especially in 
      the context of generation of an immune vaccine has not been examined. In the 
      clinic, DC vaccines are typically generated from autologous blood, therefore 
      prior exposure to substances such as alcohol may be a critical factor to consider 
      regarding the effectiveness in generating an immune response. In this study, we 
      demonstrate for the first time that ethanol differentially affects DC and tumor 
      Ag-specific T cell responses depending on sex. Signaling pathways were found to 
      be differentially regulated in DC in females compared to males and these 
      differences were exacerbated by ethanol treatment. DC from female mice treated 
      with ethanol were unable to activate Ag-specific cytotoxic T cells (CTL) as shown 
      by reduced expression of CD44, CD69, and decreased production of granzyme B and 
      IFNgamma. Furthermore, although FOXO3, an immune suppressive mediator of DC function, 
      was found to be upregulated in DC from female mice, ethanol related suppression 
      was independent of FOXO3. These findings demonstrate for the first time 
      differential impacts of alcohol on the immune system of females compared to males 
      and may be a critical consideration for determining the effectiveness of an 
      immune based therapy for cancer in patients that consume alcohol.
CI  - Copyright A(c) 2016 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Thompson, Matthew G
AU  - Thompson MG
AD  - Loyola University Chicago, Department of Surgery, Cardinal Bernardin Cancer 
      Center, Maywood, IL 60153, USA.
FAU - Navarro, Flor
AU  - Navarro F
AD  - Loyola University Chicago, Department of Surgery, Cardinal Bernardin Cancer 
      Center, Maywood, IL 60153, USA.
FAU - Chitsike, Lennox
AU  - Chitsike L
AD  - Loyola University Chicago, Department of Surgery, Cardinal Bernardin Cancer 
      Center, Maywood, IL 60153, USA.
FAU - Ramirez, Luis
AU  - Ramirez L
AD  - Loyola University Chicago, Department of Surgery, Cardinal Bernardin Cancer 
      Center, Maywood, IL 60153, USA.
FAU - Kovacs, Elizabeth J
AU  - Kovacs EJ
AD  - Loyola University Chicago, Department of Surgery, Cardinal Bernardin Cancer 
      Center, Maywood, IL 60153, USA; University of Colorado Denver, Department of 
      Surgery, Aurora, CO, USA.
FAU - Watkins, Stephanie K
AU  - Watkins SK
AD  - Loyola University Chicago, Department of Surgery, Cardinal Bernardin Cancer 
      Center, Maywood, IL 60153, USA. Electronic address: swatkins1@luc.edu.
LA  - eng
GR  - R00 CA151294/CA/NCI NIH HHS/United States
GR  - T32 AA013527/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20161018
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Forkhead Box Protein O3)
RN  - 0 (FoxO3 protein, mouse)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/drug effects/*physiology
MH  - Cells, Cultured
MH  - Dendritic Cells/drug effects/*immunology/metabolism
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Forkhead Box Protein O3/biosynthesis
MH  - Histocompatibility Antigens Class II/biosynthesis/immunology
MH  - Immunity, Cellular/drug effects/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasms/*immunology/metabolism
MH  - *Sex Characteristics
PMC - PMC5142756
MID - NIHMS825296
OTO - NOTNLM
OT  - Alcohol
OT  - Anti-tumor immunity
OT  - Cytotoxic T cell
OT  - Dendritic cell
OT  - Sex
EDAT- 2016/12/06 06:00
MHDA- 2018/01/04 06:00
PMCR- 2017/12/01
CRDT- 2016/12/06 06:00
PHST- 2016/07/01 00:00 [received]
PHST- 2016/10/17 00:00 [revised]
PHST- 2016/10/17 00:00 [accepted]
PHST- 2016/12/06 06:00 [entrez]
PHST- 2016/12/06 06:00 [pubmed]
PHST- 2018/01/04 06:00 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - S0741-8329(16)30161-6 [pii]
AID - 10.1016/j.alcohol.2016.10.007 [doi]
PST - ppublish
SO  - Alcohol. 2016 Dec;57:1-8. doi: 10.1016/j.alcohol.2016.10.007. Epub 2016 Oct 18.