PMID- 27917400
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2376-0605 (Print)
IS  - 2376-0605 (Electronic)
IS  - 2376-0605 (Linking)
VI  - 2
IP  - 4
DP  - 2016 Fall
TI  - HIGH-DOSE BIOTIN TREATMENT FOR SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS MAY 
      INTERFERE WITH THYROID ASSAYS.
PG  - e370-e373
AB  - OBJECTIVE: To review cases and increase awareness in clinicians treating patients 
      who may be taking biotin. METHODS: We describe the presentation and workup of a 
      woman with secondary progressive multiple sclerosis on high dose biotin with 
      laboratory studies suggestive of thyrotoxicosis. RESULTS: Plasma samples showed 
      laboratory evidence of elevated thyroid hormone levels with elevated free 
      thyroxine >7.8 ng/dl (reference interval (RI) 0.9-1.7 ng/dl) and decreased 
      thyroid stimulating hormone <0.02 uIU/ml (RI 0.50-5.70 uIU/ml). Laboratory values 
      normalized when biotin was withheld prior to repeat testing. CONCLUSIONS: Our 
      case report demonstrates that ingestion of high dose biotin in multiple sclerosis 
      patients can cause interference with laboratory assessment of thyroid function. 
      This interference causes laboratory values suggestive of thyrotoxicosis and can 
      lead to unnecessary evaluation. Clinicians should be aware of the risk of 
      laboratory interference in this patient demographic.
FAU - Minkovsky, Alissa
AU  - Minkovsky A
AD  - Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, 
      Boston, MA.
FAU - Lee, Mark N
AU  - Lee MN
AD  - Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, 
      Boston, MA.
FAU - Dowlatshahi, Mitra
AU  - Dowlatshahi M
AD  - Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, 
      Boston, MA.
FAU - Angell, Trevor E
AU  - Angell TE
AD  - Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, 
      Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
FAU - Mahrokhian, Lilian S
AU  - Mahrokhian LS
AD  - Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, 
      Boston, MA.
FAU - Petrides, Athena K
AU  - Petrides AK
AD  - Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, 
      Boston, MA.
FAU - Melanson, Stacy E F
AU  - Melanson SE
AD  - Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, 
      Boston, MA.
FAU - Marqusee, Ellen
AU  - Marqusee E
AD  - Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, 
      Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
FAU - Woodmansee, Whitney W
AU  - Woodmansee WW
AD  - Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, 
      Brigham and Women's Hospital/Harvard Medical School, Boston, MA.
LA  - eng
GR  - F30 AG039179/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - AACE Clin Case Rep
JT  - AACE clinical case reports
JID - 101670593
PMC - PMC5134919
MID - NIHMS827693
OTO - NOTNLM
OT  - High dose biotin
OT  - competitive immunoassay
OT  - interference
OT  - multiple sclerosis
OT  - thyrotoxicosis
EDAT- 2016/12/06 06:00
MHDA- 2016/12/06 06:01
PMCR- 2016/12/02
CRDT- 2016/12/06 06:00
PHST- 2016/12/06 06:00 [entrez]
PHST- 2016/12/06 06:00 [pubmed]
PHST- 2016/12/06 06:01 [medline]
PHST- 2016/12/02 00:00 [pmc-release]
AID - 10.4158/EP161261.CR [doi]
PST - ppublish
SO  - AACE Clin Case Rep. 2016 Fall;2(4):e370-e373. doi: 10.4158/EP161261.CR.