PMID- 27917624
OWN - NLM
STAT- MEDLINE
DCOM- 20170614
LR  - 20171116
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 15
IP  - 5
DP  - 2016 Oct
TI  - Relationships between High-mobility Group Protein B1 and Triggering Receptor 
      Expressed on Myeloid Cells Concentrations in Gingival Crevicular Fluid and 
      Chronic Periodontitis.
PG  - 381-385
AB  - One of the inflammatory mediators which is secreted by inflammatory cells is 
      high-mobility group protein B1 (HMGB1). Interaction of HMGB1 and toll-like 
      receptors (TLRs) leads to increased production of inflammatory cytokines. On the 
      other hand, it was shown that triggering receptor expressed on myeloid cells 
      (TREM-1) also can be activated by TLRs, and its soluble form (sTREM-1) can be 
      formed by cleaving of membrane-bound form of TREM-1 proteinases. Since there is 
      not enough knowledge about the precise role of HMGB1 and sTREM-1 in periodontal 
      diseases, the aim of this study was to evaluate the concentration of HMGB1 and 
      sTREM-1 in gingival crevicular fluid (GCF) samples of patients with chronic 
      periodontitis. Gingival crevicular fluid (GCF) samples were obtained from a total 
      of 24 individuals with clinically healthy gingiva and 24 patients with moderate 
      to severe chronic periodontitis. For collecting GCF samples, periopapers were 
      placed at the entrance of the crevice and left in position for 30 seconds. Then, 
      they were stored at -80 degrees C. Enzyme-linked immunosorbent assay (ELISA) was used for 
      measuring the concentration of HMGB1 and sTREM-1 in GCF samples. The 
      concentration of HMGB1 (p<0.001) and sTREM-1 (p<0.017), was significantly higher 
      in chronic periodontitis group. In addition, there was a significant positive 
      correlation between HMGB1 and sTREM-1 concentration in chronic periodontitis 
      group (p<0.05). We also found significant positive correlation between PD (Pocket 
      depth) and the concentration of HMGB1 (p<0.001) and sTREM-1 (p<0.015). It is 
      concluded that both HMGB1 and sTREM-1 are released during the inflammatory 
      response of periodontal tissues and they can promote inflammatory process, which 
      leads to tissue destruction.
FAU - Paknejad, Mojgan
AU  - Paknejad M
AD  - Dental Research Center of Tehran University of Medical Sciences, Tehran, Iran 
      AND Department of Periodontics, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Sattari, Mandana
AU  - Sattari M
AD  - Department of Immunology, Medical School, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Roozbahani, Zohreh
AU  - Roozbahani Z
AD  - Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Ershadi, Morteza
AU  - Ershadi M
AD  - Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Mehrfard, Ali
AU  - Mehrfard A
AD  - Dental School, Islamic Azad University, Tehran, Iran.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (HMGB1 Protein)
RN  - 0 (HMGB1 protein, human)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (TREM1 protein, human)
RN  - 0 (Triggering Receptor Expressed on Myeloid Cells-1)
SB  - IM
MH  - Adult
MH  - Chronic Periodontitis/*immunology/pathology
MH  - Female
MH  - Gingiva/*immunology/pathology
MH  - HMGB1 Protein/*immunology
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*immunology
MH  - Middle Aged
MH  - Receptors, Immunologic/*immunology
MH  - Triggering Receptor Expressed on Myeloid Cells-1
OTO - NOTNLM
OT  - Alarmins
OT  - Chronic periodontitis
OT  - DAMP
OT  - HMGB1
OT  - High-mobility group protein
OT  - Inflammation
OT  - sTREM1
EDAT- 2016/12/06 06:00
MHDA- 2017/06/15 06:00
CRDT- 2016/12/06 06:00
PHST- 2016/10/31 00:00 [accepted]
PHST- 2016/12/06 06:00 [entrez]
PHST- 2016/12/06 06:00 [pubmed]
PHST- 2017/06/15 06:00 [medline]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2016 Oct;15(5):381-385.