PMID- 27917684
OWN - NLM
STAT- MEDLINE
DCOM- 20180518
LR  - 20180518
IS  - 1556-9535 (Electronic)
IS  - 1556-9527 (Linking)
VI  - 36
IP  - 3
DP  - 2017 Sep
TI  - The long-term effect of oral isotretinoin therapy on macula ganglion cell complex 
      thickness.
PG  - 259-262
LID - 10.1080/15569527.2016.1265549 [doi]
AB  - PURPOSE: To evaluate the long-term effect of oral isotretinoin therapy on macula 
      ganglion cell complex (GCC) thickness by spectral domain optical coherence 
      tomography (SD-OCT). MATERIALS AND METHODS: Newly diagnosed cystic acne patients 
      who received low dose for a long time systemic isotretinoin therapy were included 
      in this study. Thorough ophthalmic evaluation and GCC thickness analysis by using 
      SD-OCT were performed at baseline, and at 1, 3, 6, and 12 months of treatment. 
      RESULTS: Forty-eight eyes of 24 patients (15 females, 9 males) were included in 
      the study. The mean age of patients was 19.37 +/- 2.74 years (range 14-25 years). 
      The full ophthalmologic examination was normal in all eyes before treatment. 
      During the treatment there were no change in visual acuity, refractive error, 
      intraocular pressure and tear break-up time. The mean GCC thicknesses were 
      81.45 +/- 4.91, 81.45 +/- 5.12, 81.81 +/- 4.68, 81.87 +/- 4.91 and 81.64 +/- 5.09 mum at 
      pretreatment and at 1, 3, 6, and 12 months of treatment, respectively 
      (p = 0.803). CONCLUSION: One-year systemic use of isotretinoin had no significant 
      effect on the thickness of macula ganglion cell. Macular ganglion cell analysis 
      is useful for determining and following the toxic effects of systemic drugs on 
      the retina. However, it is more rational to consider it as an adjunct to 
      electrophysiological testing rather than used alone.
FAU - Demirok, Gulizar
AU  - Demirok G
AD  - a Eye Department, Saglik Bakanligi Ankara Egitim ve Arastirma Hastanesi , Ankara 
      , Turkey.
FAU - Topalak, Yasemin
AU  - Topalak Y
AD  - b Eye Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey , and.
FAU - Gunduz, Ozge
AU  - Gunduz O
AD  - c Dermatology Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey.
FAU - Yildirim, Dilsun
AU  - Yildirim D
AD  - c Dermatology Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey.
FAU - Kocamaz, Mehmet Fatih
AU  - Kocamaz MF
AD  - b Eye Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey , and.
FAU - Sengun, Ahmet
AU  - Sengun A
AD  - b Eye Department , Ufuk Universitesi Tip Fakultesi , Ankara , Turkey , and.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170111
PL  - England
TA  - Cutan Ocul Toxicol
JT  - Cutaneous and ocular toxicology
JID - 101266892
RN  - 0 (Dermatologic Agents)
RN  - EH28UP18IF (Isotretinoin)
SB  - IM
MH  - Acne Vulgaris/drug therapy
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Dermatologic Agents/*pharmacology/therapeutic use
MH  - Female
MH  - Humans
MH  - Intraocular Pressure/drug effects
MH  - Isotretinoin/*pharmacology/therapeutic use
MH  - Macula Lutea/cytology/drug effects
MH  - Male
MH  - Retinal Ganglion Cells/cytology/*drug effects
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/drug effects
MH  - Young Adult
OTO - NOTNLM
OT  - Ganglion cell complex layer
OT  - macular ganglion cell analysis
OT  - optical coherence tomography
OT  - retinal toxicity
OT  - systemic isotretinoin therapy
EDAT- 2016/12/06 06:00
MHDA- 2018/05/19 06:00
CRDT- 2016/12/06 06:00
PHST- 2016/12/06 06:00 [pubmed]
PHST- 2018/05/19 06:00 [medline]
PHST- 2016/12/06 06:00 [entrez]
AID - 10.1080/15569527.2016.1265549 [doi]
PST - ppublish
SO  - Cutan Ocul Toxicol. 2017 Sep;36(3):259-262. doi: 10.1080/15569527.2016.1265549. 
      Epub 2017 Jan 11.