PMID- 27918538
OWN - NLM
STAT- MEDLINE
DCOM- 20170907
LR  - 20221207
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Linking)
VI  - 49
IP  - 1
DP  - 2017 Jan
TI  - Variation in the flowering gene SELF PRUNING 5G promotes day-neutrality and early 
      yield in tomato.
PG  - 162-168
LID - 10.1038/ng.3733 [doi]
AB  - Plants evolved so that their flowering is triggered by seasonal changes in day 
      length. However, day-length sensitivity in crops limits their geographical range 
      of cultivation, and thus modification of the photoperiod response was critical 
      for their domestication. Here we show that loss of day-length-sensitive flowering 
      in tomato was driven by the florigen paralog and flowering repressor SELF-PRUNING 
      5G (SP5G). SP5G expression is induced to high levels during long days in wild 
      species, but not in cultivated tomato because of cis-regulatory variation. 
      CRISPR/Cas9-engineered mutations in SP5G cause rapid flowering and enhance the 
      compact determinate growth habit of field tomatoes, resulting in a quick burst of 
      flower production that translates to an early yield. Our findings suggest that 
      pre-existing variation in SP5G facilitated the expansion of cultivated tomato 
      beyond its origin near the equator in South America, and they provide a 
      compelling demonstration of the power of gene editing to rapidly improve yield 
      traits in crop breeding.
FAU - Soyk, Sebastian
AU  - Soyk S
AD  - Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
FAU - Muller, Niels A
AU  - Muller NA
AD  - Department of Plant Breeding and Genetics, Max Planck Institute for Plant 
      Breeding Research, Cologne, Germany.
FAU - Park, Soon Ju
AU  - Park SJ
AD  - Division of Biological Sciences, Wonkwang University, Iksan, Republic of Korea.
FAU - Schmalenbach, Inga
AU  - Schmalenbach I
AD  - Department of Plant Breeding and Genetics, Max Planck Institute for Plant 
      Breeding Research, Cologne, Germany.
FAU - Jiang, Ke
AU  - Jiang K
AD  - Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
FAU - Hayama, Ryosuke
AU  - Hayama R
AD  - Department of Plant Developmental Biology, Max Planck Institute for Plant 
      Breeding Research, Cologne, Germany.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Plant Breeding and Genetics, Max Planck Institute for Plant 
      Breeding Research, Cologne, Germany.
FAU - Van Eck, Joyce
AU  - Van Eck J
AD  - The Boyce Thompson Institute, Ithaca, New York, USA.
FAU - Jimenez-Gomez, Jose M
AU  - Jimenez-Gomez JM
AUID- ORCID: 0000-0002-5033-7192
AD  - Department of Plant Breeding and Genetics, Max Planck Institute for Plant 
      Breeding Research, Cologne, Germany.
AD  - Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Universite Paris-Saclay, 
      Versailles, France.
FAU - Lippman, Zachary B
AU  - Lippman ZB
AD  - Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20161205
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (Plant Proteins)
SB  - IM
MH  - CRISPR-Cas Systems
MH  - Flowers/genetics/*growth & development
MH  - *Gene Expression Regulation, Plant
MH  - Solanum lycopersicum/genetics/*growth & development
MH  - Mutation/*genetics
MH  - Phenotype
MH  - Plant Proteins/antagonists & inhibitors/*genetics/metabolism
MH  - Plants, Genetically Modified/genetics/*growth & development
MH  - Regulatory Sequences, Nucleic Acid/genetics
MH  - Time Factors
EDAT- 2016/12/06 06:00
MHDA- 2017/09/08 06:00
CRDT- 2016/12/06 06:00
PHST- 2016/07/11 00:00 [received]
PHST- 2016/10/31 00:00 [accepted]
PHST- 2016/12/06 06:00 [pubmed]
PHST- 2017/09/08 06:00 [medline]
PHST- 2016/12/06 06:00 [entrez]
AID - ng.3733 [pii]
AID - 10.1038/ng.3733 [doi]
PST - ppublish
SO  - Nat Genet. 2017 Jan;49(1):162-168. doi: 10.1038/ng.3733. Epub 2016 Dec 5.