PMID- 27919164
OWN - NLM
STAT- MEDLINE
DCOM- 20171225
LR  - 20181202
IS  - 1091-7691 (Electronic)
IS  - 0895-8378 (Linking)
VI  - 28
IP  - 14
DP  - 2016 Dec
TI  - Differences in allergic inflammatory responses in murine lungs: comparison of 
      PM2.5 and coarse PM collected during the hazy events in a Chinese city.
PG  - 706-718
AB  - Urban particulate matter (PM) is associated with an increase in asthma. PM2.5 
      (<PM2.5 mum) and coarse PM (CPM: PM2.5-PM10 mum) were collected from the air in a 
      Chinese city during haze events. The amounts of polycyclic aromatic hydrocarbons 
      (PAHs) were higher in PM2.5 than in CPM. Conversely, microbial elements LPS and 
      beta-glucan were much higher in CPM than in PM2.5. Concentrations of Si, Al, Fe, and 
      Ti in CPM were greater than in PM2.5, while Pb, Cu and As concentrations were 
      lower than in PM2.5. When RAW264.7 cells were treated with PM2.5 and CPM, the 
      pro-inflammatory response in the cells was associated with the microbial element 
      levels and attenuated partly by both polymyxin B (PMB) and N-acetylcystein (NAC). 
      The expression of the oxidative stress response gene heme oxygenase1 was 
      associated with PAHs levels. The exacerbating effects of the two-types of PM on 
      murine lung eosinophilia were compared to clarify the role of toxic materials. 
      When BALB/c mice were intratracheally instilled with PM2.5 or CPM (total 
      0.4 mg) + ovalbumin (OVA), both exacerbated lung eosinophilia along with 
      allergy-relevant biological indicators, such as OVA-specific IgE in serum; 
      enhancement of lung pathology when compared with counterpart samples without OVA. 
      The exacerbating effects were greater in microbial element-rich CPM than in 
      organic chemical-rich PM2.5. These results indicate that microbial elements have 
      more potently exacerbating effects on the development of lung eosinophilia than 
      do organic chemicals. In addition, oxidative stress and transition metals might 
      be associated with the exacerbation of this negative effect.
FAU - He, Miao
AU  - He M
AD  - a School of Public Health, China Medical University , Shenyang , China.
AD  - b Department of Health Sciences , Oita University of Nursing and Health Sciences 
      , Oita , Japan.
FAU - Ichinose, Takamichi
AU  - Ichinose T
AD  - b Department of Health Sciences , Oita University of Nursing and Health Sciences 
      , Oita , Japan.
FAU - Yoshida, Seiichi
AU  - Yoshida S
AD  - b Department of Health Sciences , Oita University of Nursing and Health Sciences 
      , Oita , Japan.
FAU - Shiba, Fumiko
AU  - Shiba F
AD  - b Department of Health Sciences , Oita University of Nursing and Health Sciences 
      , Oita , Japan.
FAU - Arashidani, Keiichi
AU  - Arashidani K
AD  - c Department of Immunology and Parasitology , School of Medicine, University of 
      Occupational and Environmental Health , Fukuoka , Japan.
FAU - Takano, Hirohisa
AU  - Takano H
AD  - d Environmental Health Division, Department of Environmental Engineering, 
      Graduate School of Engineering, Kyoto University , Kyoto , Japan , and.
FAU - Sun, Guifan
AU  - Sun G
AD  - a School of Public Health, China Medical University , Shenyang , China.
FAU - Shibamoto, Takayuki
AU  - Shibamoto T
AD  - e Department of Environmental Toxicology , University of California , Davis , CA 
      , USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20161205
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Air Pollutants)
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Proteins)
RN  - 0 (Particulate Matter)
RN  - 0 (beta-Glucans)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nos2 protein, mouse)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 1.14.14.18 (Hmox1 protein, mouse)
SB  - IM
MH  - Air Pollutants/*chemistry/*toxicity
MH  - Allergens
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/chemistry/cytology
MH  - Cell Count
MH  - China
MH  - Cities
MH  - Cytokines/immunology
MH  - Heme Oxygenase-1/genetics
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Lipopolysaccharides/analysis
MH  - Lung/drug effects/pathology
MH  - Male
MH  - Membrane Proteins/genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nitric Oxide Synthase Type II/genetics
MH  - Ovalbumin
MH  - Particle Size
MH  - Particulate Matter/*chemistry/*toxicity
MH  - *Pulmonary Eosinophilia/blood/etiology/immunology/pathology
MH  - RAW 264.7 Cells
MH  - *Respiratory Hypersensitivity/blood/etiology/immunology/pathology
MH  - beta-Glucans/analysis
OTO - NOTNLM
OT  - PM2.5
OT  - coarse PM
OT  - lung eosinophilia
OT  - metals
OT  - microbial elements
OT  - polycyclic aromatic hydrocarbons
EDAT- 2016/12/07 06:00
MHDA- 2017/12/26 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2017/12/26 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
AID - 10.1080/08958378.2016.1260185 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2016 Dec;28(14):706-718. doi: 10.1080/08958378.2016.1260185. Epub 
      2016 Dec 5.