PMID- 27919187
OWN - NLM
STAT- MEDLINE
DCOM- 20180112
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 58
IP  - 7
DP  - 2017 Jul
TI  - Diagnostic value of serum ferritin and the risk factors and cytokine profiles of 
      hemophagocytic syndrome following allogeneic hematopoietic cell transplantation.
PG  - 1664-1672
LID - 10.1080/10428194.2016.1262034 [doi]
AB  - To examine the diagnostic value of serum ferritin, the associated risk factors, 
      and cytokine profiles of hemophagocytic syndrome (HPS) following allogeneic 
      hematopoietic cell transplantation (allo-HCT), we retrospectively analyzed data 
      from patients undergoing allo-HCT between 2006 and 2012. Of 223 eligible 
      patients, 18 patients developed HPS. A serum ferritin level above 30,000 mug/l was 
      highly specific for the detection of HPS (specificity, 93%). The one-year 
      survival rate for HPS was significantly lower than that of non-HPS patients 
      (37.5% vs. 72.9%, respectively, Log-rank p < .01). In multivariable Cox models, 
      antigen mismatches in human leukocyte antigen (HLA) in both graft-versus-host 
      (GVH) and host-versus-graft (HVG) directions were significantly associated with 
      the incidence of HPS. We found a significant elevation of Th1 cytokine (IFN-gamma), 
      Th2 cytokines (IL-10), and chemokines (MCP-1 and IP-10), at the onset of HPS. Our 
      results suggest that allo-reactivity, derived from HLA-mismatch, and possibly 
      causing a cytokine storm, may be associated with HPS development.
FAU - Nanno, Satoru
AU  - Nanno S
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Koh, Hideo
AU  - Koh H
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Nakashima, Yasuhiro
AU  - Nakashima Y
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Katayama, Takako
AU  - Katayama T
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Okamura, Hiroshi
AU  - Okamura H
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Koh, Shiro
AU  - Koh S
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Yoshimura, Takuro
AU  - Yoshimura T
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Nishimoto, Mitsutaka
AU  - Nishimoto M
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Hayashi, Yoshiki
AU  - Hayashi Y
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Nakamae, Mika
AU  - Nakamae M
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Hirose, Asao
AU  - Hirose A
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Nakane, Takahiko
AU  - Nakane T
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Hino, Masayuki
AU  - Hino M
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
FAU - Nakamae, Hirohisa
AU  - Nakamae H
AD  - a Hematology, Graduate School of Medicine , Osaka City University , Osaka , 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161206
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
RN  - 9007-73-2 (Ferritins)
SB  - IM
CIN - Leuk Lymphoma. 2018 Mar;59(3):770-771. PMID: 28535080
CIN - Leuk Lymphoma. 2018 Mar;59(3):772-773. PMID: 28776428
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - Cytokines/*blood
MH  - Female
MH  - Ferritins/*blood
MH  - Graft vs Host Disease/diagnosis/etiology/prevention & control
MH  - HLA Antigens/genetics/immunology
MH  - Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - Lymphohistiocytosis, Hemophagocytic/*blood/*diagnosis/mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Analysis
MH  - Transplantation, Homologous
MH  - Young Adult
OTO - NOTNLM
OT  - Hemophagocytic syndrome
OT  - allogeneic hematopoietic cell transplantation
OT  - risk factor
OT  - serum cytokine profile
OT  - serum ferritin
EDAT- 2016/12/07 06:00
MHDA- 2018/01/13 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
AID - 10.1080/10428194.2016.1262034 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2017 Jul;58(7):1664-1672. doi: 10.1080/10428194.2016.1262034. Epub 
      2016 Dec 6.