PMID- 27919453
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20221207
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 36
IP  - 12
DP  - 2016 Dec
TI  - Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid 
      profiles in patients with type 2 diabetes: a randomized controlled trial.
PG  - 1392-1401
LID - S0271-5317(16)30673-X [pii]
LID - 10.1016/j.nutres.2016.11.007 [doi]
AB  - Tartary buckwheat (TB) is rich in protein, dietary fiber, and flavonoids and has 
      been reported to affect type 2 diabetes mellitus (T2DM) in animal experiments, 
      but limited information on the benefit of TB as a whole food in T2DM patients is 
      available. Thus, we tested the hypothesis that a daily replacement of a portion 
      of the staple food with TB will improve risk factors of T2DM, including fasting 
      glucose, insulin resistance, and lipid profile. In a parallel, randomized, 
      open-label, controlled trial, 165 T2DM patients were randomly assigned to a 
      control diet group (DC group; systematic diet plans and intensive nutritional 
      education) or a TB intervention group (TB group; daily replacement of a portion 
      of staple food with TB food). Blood samples and diet information were collected 
      at baseline and after 4 weeks of intervention. The TB group decreased fasting 
      insulin (2.46-2.39 Ln mU/L), total cholesterol (5.08-4.79 mmol/L), and 
      low-density lipoprotein cholesterol (3.00-2.80 mmol/L) compared with the DC group 
      at 4 weeks (P<.05). No significant differences in blood glucose or glycated 
      hemoglobin levels were noted between the TB and DC groups. In addition, subgroup 
      analyses based on daily TB intake dose showed a reduction in insulin, total 
      cholesterol, and low-density lipoprotein cholesterol, but also insulin resistance 
      was observed when TB intake dose was greater than 110 g/d. These results support 
      the hypothesis that TB may improve insulin resistance and lipid profile in T2DM 
      patients.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Qiu, Ju
AU  - Qiu J
AD  - Institute of Food and Nutrition Development, Ministry of Agriculture, Haidian, 
      Beijing 100081, China.
FAU - Liu, Yanping
AU  - Liu Y
AD  - Peking Union Medical College Hospital, Dongcheng, Beijing 100730, China.
FAU - Yue, Yanfen
AU  - Yue Y
AD  - Pinggu Hospital of Traditional Chinese Medicine, Pinggu, Beijing 101200, China.
FAU - Qin, Yuchang
AU  - Qin Y
AD  - Institute of Food and Nutrition Development, Ministry of Agriculture, Haidian, 
      Beijing 100081, China.
FAU - Li, Zaigui
AU  - Li Z
AD  - College of Food Science and Nutritional Engineering, China Agricultural 
      University, Haidian, Beijing 100083, China. Electronic address: lizg@cau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161117
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Cholesterol/*blood
MH  - Cholesterol, LDL/blood
MH  - Diabetes Mellitus, Type 2/blood/*diet therapy
MH  - *Diet
MH  - Energy Intake
MH  - Fagopyrum/*chemistry
MH  - Fasting
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/*blood
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Dietary intervention
OT  - Insulin resistance
OT  - Lipid
OT  - Tartary buckwheat
OT  - Type 2 diabetes mellitus
EDAT- 2016/12/07 06:00
MHDA- 2018/01/09 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/05/24 00:00 [received]
PHST- 2016/11/14 00:00 [revised]
PHST- 2016/11/15 00:00 [accepted]
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
AID - S0271-5317(16)30673-X [pii]
AID - 10.1016/j.nutres.2016.11.007 [doi]
PST - ppublish
SO  - Nutr Res. 2016 Dec;36(12):1392-1401. doi: 10.1016/j.nutres.2016.11.007. Epub 2016 
      Nov 17.