PMID- 27919646
OWN - NLM
STAT- MEDLINE
DCOM- 20180209
LR  - 20180816
IS  - 1879-0305 (Electronic)
IS  - 1359-6101 (Linking)
VI  - 34
DP  - 2017 Apr
TI  - Role of neurotrophic factors in attention deficit hyperactivity disorder.
PG  - 35-41
LID - S1359-6101(16)30138-1 [pii]
LID - 10.1016/j.cytogfr.2016.11.003 [doi]
AB  - Neurotrophins (NTs), a family of proteins including nerve growth factor, 
      brain-derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4, are 
      essential for neural growth, survival, and differentiation, and are therefore 
      crucial for brain development. Attention deficit hyperactivity disorder (ADHD) is 
      a neurodevelopmental disorder characterized by problems of inattention and/or 
      hyperactivity-impulsivity. ADHD is one of the most common childhood onset 
      psychiatric disorders. Studies have suggested that both genetic and environmental 
      factors influence the development of the disorder, although the precise causes of 
      ADHD have not yet been identified. In this review, we assess the role of NTs in 
      the pathophysiology of ADHD. Preclinical evidence indicates that BDNF knockout 
      mice are hyperactive, and an ADHD rodent model exhibited decreased cerebral BDNF 
      levels. Several lines of evidence from clinical studies, including blood level 
      and genetic studies, have suggested that NTs are involved in the pathogenesis of 
      ADHD and in the mechanism of biological treatments for ADHD. Future directions 
      for research are proposed, such as using blood NTs as ADHD biomarkers, optimizing 
      NT genetic studies in ADHD, considering NTs as a link between ADHD and other 
      comorbid mental disorders, and investigating methods for optimally modulating NT 
      signaling to discover novel therapeutics for treating ADHD.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
AD  - Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; 
      School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic 
      address: tsai610913@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161130
PL  - England
TA  - Cytokine Growth Factor Rev
JT  - Cytokine & growth factor reviews
JID - 9612306
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Attention Deficit Disorder with Hyperactivity/*physiopathology/therapy
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/blood/genetics/*physiology/therapeutic use
MH  - Child
MH  - Clinical Studies as Topic
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Nerve Growth Factors/blood/genetics/*physiology/therapeutic use
OTO - NOTNLM
OT  - Attention deficit hyperactivity disorder
OT  - BDNF
OT  - Neurotrophins
EDAT- 2016/12/07 06:00
MHDA- 2018/02/10 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/10/24 00:00 [received]
PHST- 2016/11/15 00:00 [revised]
PHST- 2016/11/25 00:00 [accepted]
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2018/02/10 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
AID - S1359-6101(16)30138-1 [pii]
AID - 10.1016/j.cytogfr.2016.11.003 [doi]
PST - ppublish
SO  - Cytokine Growth Factor Rev. 2017 Apr;34:35-41. doi: 
      10.1016/j.cytogfr.2016.11.003. Epub 2016 Nov 30.