PMID- 27919654 OWN - NLM STAT- MEDLINE DCOM- 20170802 LR - 20220408 IS - 1873-1449 (Electronic) IS - 1538-4721 (Linking) VI - 16 IP - 1 DP - 2017 Jan-Feb TI - American Brachytherapy Society: Brachytherapy treatment recommendations for locally advanced cervix cancer for low-income and middle-income countries. PG - 85-94 LID - S1538-4721(16)30572-4 [pii] LID - 10.1016/j.brachy.2016.10.007 [doi] AB - PURPOSE: Most cervix cancer cases occur in low-income and middle-income countries (LMIC), and outcomes are suboptimal, even for early stage disease. Brachytherapy plays a central role in the treatment paradigm, improving both local control and overall survival. The American Brachytherapy Society (ABS) aims to provide guidelines for brachytherapy delivery in resource-limited settings. METHODS AND MATERIALS: A panel of clinicians and physicists with expertise in brachytherapy administration in LMIC was convened. A survey was developed to identify practice patterns at the authors' institutions and was also extended to participants of the Cervix Cancer Research Network. The scientific literature was reviewed to identify consensus papers or review articles with a focus on treatment of locally advanced, unresected cervical cancer in LMIC. RESULTS: Of the 40 participants invited to respond to the survey, 32 responded (response rate 80%). Participants were practicing in 14 different countries including both high-income (China, Singapore, Taiwan, United Kingdom, and United States) and low-income or middle-income countries (Bangladesh, Botswana, Brazil, India, Malaysia, Pakistan, Philippines, Thailand, and Vietnam). Recommendations for modifications to existing ABS guidelines were reviewed by the panel members and are highlighted in this article. CONCLUSIONS: Recommendations for treatment of locally advanced, unresectable cervical cancer in LMIC are presented. The guidelines comment on staging, external beam radiotherapy, use of concurrent chemotherapy, overall treatment duration, use of anesthesia, applicator choice and placement verification, brachytherapy treatment planning including dose and prescription point, recommended reporting and documentation, physics support, and follow-up. CI - Copyright (c) 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved. FAU - Suneja, Gita AU - Suneja G AD - Duke University, Durham, NC. Electronic address: Gita.suneja@icloud.com. FAU - Brown, Derek AU - Brown D AD - University of California San Diego, San Diego, CA. FAU - Chang, Amy AU - Chang A AD - Pamela Youde Nethersole Eastern Hospital, Hong Kong. FAU - Erickson, Beth AU - Erickson B AD - Medical College of Wisconsin, Milwaukee, WI. FAU - Fidarova, Elena AU - Fidarova E AD - International Atomic Energy Agency, Vienna, Austria. FAU - Grover, Surbhi AU - Grover S AD - University of Pennsylvania, Philadelphia, PA; Princess Marina Hospital, Gaborone, Botswana. FAU - Mahantshetty, Umesh AU - Mahantshetty U AD - Tata Memorial Center, Mumbai, India. FAU - Nag, Subir AU - Nag S AD - Kaiser Permanente, Santa Clara, CA. FAU - Narayan, Kailash AU - Narayan K AD - Peter MacCallum Cancer Centre, Melbourne, Australia. FAU - Bvochora-Nsingo, Memory AU - Bvochora-Nsingo M AD - Gaborone Private Hospital, Gaborone, Botswana. FAU - Viegas, Celia AU - Viegas C AD - Instituto Nacional de Cancer- INCA, Rio de Janeiro, Brazil. FAU - Viswanathan, Akila N AU - Viswanathan AN AD - Johns Hopkins University, Baltimore, MD. FAU - Lin, Ming Yin AU - Lin MY AD - Peter MacCallum Cancer Centre, Melbourne, Australia. FAU - Gaffney, David AU - Gaffney D AD - University of Utah, Salt Lake City, UT. LA - eng PT - Journal Article PT - Practice Guideline DEP - 20161203 PL - United States TA - Brachytherapy JT - Brachytherapy JID - 101137600 SB - IM MH - Brachytherapy/*methods/standards MH - Developing Countries MH - Female MH - Health Resources MH - Humans MH - Radiation Oncology MH - Radiotherapy MH - Radiotherapy Dosage MH - Societies, Medical MH - United States MH - Uterine Cervical Neoplasms/pathology/*radiotherapy OTO - NOTNLM OT - Brachytherapy OT - Cervix cancer OT - Consensus guidelines OT - Global oncology OT - Low-resource setting EDAT- 2016/12/07 06:00 MHDA- 2017/08/03 06:00 CRDT- 2016/12/07 06:00 PHST- 2016/07/28 00:00 [received] PHST- 2016/09/06 00:00 [revised] PHST- 2016/10/21 00:00 [accepted] PHST- 2016/12/07 06:00 [pubmed] PHST- 2017/08/03 06:00 [medline] PHST- 2016/12/07 06:00 [entrez] AID - S1538-4721(16)30572-4 [pii] AID - 10.1016/j.brachy.2016.10.007 [doi] PST - ppublish SO - Brachytherapy. 2017 Jan-Feb;16(1):85-94. doi: 10.1016/j.brachy.2016.10.007. Epub 2016 Dec 3.