PMID- 27920202
OWN - NLM
STAT- MEDLINE
DCOM- 20170601
LR  - 20210205
IS  - 1083-351X (Electronic)
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 292
IP  - 3
DP  - 2017 Jan 20
TI  - The Translational Significance of the Neurovascular Unit.
PG  - 762-770
LID - 10.1074/jbc.R116.760215 [doi]
AB  - The mammalian brain is supplied with blood by specialized vasculature that is 
      structurally and functionally distinct from that of the periphery. A defining 
      feature of this vasculature is a physical blood-brain barrier (BBB). The BBB 
      separates blood components from the brain microenvironment, regulating the entry 
      and exit of ions, nutrients, macromolecules, and energy metabolites. Over the 
      last two decades, physiological studies of cerebral blood flow dynamics have 
      demonstrated that substantial intercellular communication occurs between cells of 
      the vasculature and the neurons and glia that abut the vasculature. These 
      findings suggest that the BBB does not function independently, but as a module 
      within the greater context of a multicellular neurovascular unit (NVU) that 
      includes neurons, astrocytes, pericytes, and microglia as well as the blood 
      vessels themselves. Here, we describe the roles of these NVU components as well 
      as how they act in concert to modify cerebrovascular function and permeability in 
      health and in select diseases.
CI  - (c) 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
FAU - McConnell, Heather L
AU  - McConnell HL
AD  - From the Departments of Neurology, Pathology, Neurosurgery, and Veterans Affairs, 
      Oregon Health & Science University, Portland, Oregon 97239-2941.
FAU - Kersch, Cymon N
AU  - Kersch CN
AD  - From the Departments of Neurology, Pathology, Neurosurgery, and Veterans Affairs, 
      Oregon Health & Science University, Portland, Oregon 97239-2941.
FAU - Woltjer, Randall L
AU  - Woltjer RL
AD  - From the Departments of Neurology, Pathology, Neurosurgery, and Veterans Affairs, 
      Oregon Health & Science University, Portland, Oregon 97239-2941.
FAU - Neuwelt, Edward A
AU  - Neuwelt EA
AD  - From the Departments of Neurology, Pathology, Neurosurgery, and Veterans Affairs, 
      Oregon Health & Science University, Portland, Oregon 97239-2941 
      neuwelte@ohsu.edu.
LA  - eng
GR  - R01 CA137488/CA/NCI NIH HHS/United States
GR  - R01 CA199111/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20161205
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
SB  - IM
MH  - Animals
MH  - Astrocytes/cytology/*metabolism
MH  - Blood-Brain Barrier/cytology/*metabolism
MH  - Humans
MH  - Microglia/cytology/*metabolism
MH  - Neurons/cytology/*metabolism
MH  - Pericytes/cytology/*metabolism
PMC - PMC5247651
OTO - NOTNLM
OT  - blood-brain barrier
OT  - brain
OT  - brain tumor
OT  - cerebrovasculature
OT  - glioblastoma
OT  - neurovascular unit
OT  - vascular endothelial growth factor (VEGF)
OT  - vasculogenesis
EDAT- 2016/12/07 06:00
MHDA- 2017/06/02 06:00
PMCR- 2018/01/20
CRDT- 2016/12/07 06:00
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2017/06/02 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
PHST- 2018/01/20 00:00 [pmc-release]
AID - S0021-9258(20)40258-3 [pii]
AID - R116.760215 [pii]
AID - 10.1074/jbc.R116.760215 [doi]
PST - ppublish
SO  - J Biol Chem. 2017 Jan 20;292(3):762-770. doi: 10.1074/jbc.R116.760215. Epub 2016 
      Dec 5.