PMID- 27921148
OWN - NLM
STAT- MEDLINE
DCOM- 20171103
LR  - 20181113
IS  - 1863-2300 (Electronic)
IS  - 1863-2297 (Linking)
VI  - 39
IP  - 2
DP  - 2017 Feb
TI  - Metabolites: deciphering the molecular language between DCs and their 
      environment.
PG  - 177-198
LID - 10.1007/s00281-016-0609-6 [doi]
AB  - Dendritic cells (DCs) determine the outcome of the immune response based on 
      signals they receive from the environment. Presentation of antigen under various 
      contexts can lead to activation and differentiation of T cells for immunity or 
      dampening of immune responses by establishing tolerance, primarily through the 
      priming of regulatory T cells. Infections, inflammation and normal cellular 
      interactions shape DC responses through direct contact or via cytokine signaling. 
      Although it is widely accepted that DCs sense microbial components through 
      pattern recognition receptors (PRRs), increasing evidence advocates for the 
      existence of a set of signals that can profoundly shape DC function via 
      PRR-independent pathways. This diverse group of host- or commensal-derived 
      metabolites represents a newly appreciated code from which DCs can interpret 
      environmental cues. In this review, we discuss the existing information on the 
      effect of some of the most studied metabolites on DC function, together with the 
      implications this may have in immune-mediated diseases.
FAU - Minarrieta, Lucia
AU  - Minarrieta L
AD  - Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical 
      Infection Research, a joint venture between the Medical School Hannover (MHH) and 
      the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen Strasse 7, 30625, 
      Hannover, Germany.
FAU - Ghorbani, Peyman
AU  - Ghorbani P
AD  - Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical 
      Infection Research, a joint venture between the Medical School Hannover (MHH) and 
      the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen Strasse 7, 30625, 
      Hannover, Germany.
FAU - Sparwasser, Tim
AU  - Sparwasser T
AD  - Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical 
      Infection Research, a joint venture between the Medical School Hannover (MHH) and 
      the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen Strasse 7, 30625, 
      Hannover, Germany.
FAU - Berod, Luciana
AU  - Berod L
AD  - Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical 
      Infection Research, a joint venture between the Medical School Hannover (MHH) and 
      the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen Strasse 7, 30625, 
      Hannover, Germany. berod.luciana@mh-hannover.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20161205
PL  - Germany
TA  - Semin Immunopathol
JT  - Seminars in immunopathology
JID - 101308769
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - *Cellular Microenvironment
MH  - Dendritic Cells/classification/cytology/*immunology/*metabolism
MH  - Energy Metabolism
MH  - Humans
MH  - *Metabolome
MH  - Organ Specificity/immunology
MH  - Phenotype
MH  - Signal Transduction
OTO - NOTNLM
OT  - Dendritic cells
OT  - Metabolism
OT  - Metabolites
OT  - Microbiota
OT  - Tolerance
OT  - Vitamins
EDAT- 2016/12/07 06:00
MHDA- 2017/11/04 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/07/08 00:00 [received]
PHST- 2016/11/14 00:00 [accepted]
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2017/11/04 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
AID - 10.1007/s00281-016-0609-6 [pii]
AID - 10.1007/s00281-016-0609-6 [doi]
PST - ppublish
SO  - Semin Immunopathol. 2017 Feb;39(2):177-198. doi: 10.1007/s00281-016-0609-6. Epub 
      2016 Dec 5.