PMID- 27921409
OWN - NLM
STAT- MEDLINE
DCOM- 20170614
LR  - 20170614
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 15
IP  - 4
DP  - 2016 Aug
TI  - HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with 
      Recurrent Aphthous Stomatitis.
PG  - 289-295
AB  - Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease 
      of the oral cavity, which affects a range of 5-25% of the population. RAS appears 
      to be associated with some human leukocyte antigen (HLA) class II alleles and 
      haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB 
      alleles among Iranian RAS patients and healthy controls. In order to evaluate the 
      association of HLA-DR and DQ alleles and haplotypes, 54 patients with RAS and 100 
      unrelated healthy subjects as control group were investigated. Our data indicated 
      that DRB1*13:17, DRB1*15:01, and DRB5*01 were significantly more frequent in RAS 
      patients in comparison to controls. However, DRB3:01allele frequency was higher 
      in the controls compared to the patients. The significantly frequent allele in 
      the patients compared with the healthy subjects was HLA-DQB1*03:02. However, both 
      HLA-DQB1*02:01 and HLA-DQB1*03:01 alleles were most frequent in the healthy 
      individuals rather than the patients. The DRB*04/DQB1*03:01 and 
      DRB*01:01/DQB1*02:01 haplotypes were significantly distributed in healthy 
      subjects compared with patients. However, DRB*07:01/DQB1*03:02 haplotype was 
      found to be significantly frequent in patients than controls. In respect of HLA 
      genes, factors are involved in the incidence of RAS; various HLA-DRB and HLA-DQB1 
      alleles and the related haplotypes are suggested to be the three main RAS 
      susceptibility factors in our population study.
FAU - Najafi, Shamsolmoulouk
AU  - Najafi S
AD  - Dental Research Center, School of Dentistry, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Mohammadzadeh, Mahsa
AU  - Mohammadzadeh M
AD  - Department of Orthodontic, Dental Branch, Islamic Azad University, Tehran, Iran.
FAU - Zare Bidoki, Alireza
AU  - Zare Bidoki A
AD  - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, 
      Fasa, Iran AND Thrombosis Hemostasis Research Center, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Meighani, Ghasem
AU  - Meighani G
AD  - Department of Pediatrics , School of Dentistry, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Aslani, Saeed
AU  - Aslani S
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran AND Department of Immunology, School of Medicine, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Rezaei, Nima
AU  - Rezaei N
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran AND Research Center for Immunodeficiencies, Children's 
      Medical Center, Tehran University of Medical Sciences, Tehran, Iran AND Universal 
      Scientific Education and Research Network (USERN), Tehran, Iran.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQbeta antigen)
RN  - 0 (HLA-DR beta-Chains)
RN  - Sutton disease 2
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Female
MH  - *Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ beta-Chains/*genetics/immunology
MH  - HLA-DR beta-Chains/*genetics/immunology
MH  - *Haplotypes
MH  - Humans
MH  - Male
MH  - Stomatitis, Aphthous/epidemiology/*genetics/immunology
OTO - NOTNLM
OT  - Allele frequency
OT  - Haplotype frequency
OT  - Human leukocyte antigen
OT  - Recurrent aphthous stomatitis
EDAT- 2016/12/07 06:00
MHDA- 2017/06/15 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/08/30 00:00 [accepted]
PHST- 2016/12/07 06:00 [entrez]
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2017/06/15 06:00 [medline]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2016 Aug;15(4):289-295.