PMID- 27922138
OWN - NLM
STAT- MEDLINE
DCOM- 20181026
LR  - 20181026
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 9
IP  - 1
DP  - 2017 Jan 7
TI  - Mitomycin C-treated human-induced pluripotent stem cells as a safe delivery 
      system of gold nanorods for targeted photothermal therapy of gastric cancer.
PG  - 334-340
LID - 10.1039/c6nr06851k [doi]
AB  - Human-induced pluripotent stem cells (iPS) possess an intrinsic tumor tropism 
      ability. However, iPS cells are impeded in clinical applications of tumor therapy 
      due to the formation of teratomas and their survival in normal organs such as the 
      liver, lungs, spleen and kidneys. Mitomycin C (MMC) can overcome this limitation 
      by suppressing iPS proliferation. Herein, we fabricated a safe delivery system of 
      iPS cells treated with MMC loading with gold nanorods (AuNRs) for the targeted 
      photothermal treatment of gastric cancer. Our results showed that the tumor cells 
      were efficiently killed by the heat generated from the gold nanorods, and the iPS 
      cells ultimately died due to the action of MMC seven days after the photothermal 
      treatment. This suggested that pre-treated iPS cells with MMC can be used as a 
      novel and safe approach for targeted tumor therapy. This paves the road for 
      clinical translation in the future.
FAU - Yang, Meng
AU  - Yang M
AD  - Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research 
      Centre for Intelligent Diagnosis and Treatment Instrument, Department of 
      Instrument Science and Engineering, School of Electronic Information and 
      Electrical Engineering, National Center for Translational Medicine, Shanghai Jiao 
      Tong University, Shanghai 200240, P.R. China. dxcui@sjtu.edu.cn.
FAU - Liu, Yanlei
AU  - Liu Y
FAU - Hou, Wenxiu
AU  - Hou W
FAU - Zhi, Xiao
AU  - Zhi X
FAU - Zhang, Chunlei
AU  - Zhang C
FAU - Jiang, Xinquan
AU  - Jiang X
FAU - Pan, Fei
AU  - Pan F
FAU - Yang, Yuming
AU  - Yang Y
FAU - Ni, Jian
AU  - Ni J
FAU - Cui, Daxiang
AU  - Cui D
LA  - eng
PT  - Journal Article
DEP - 20161206
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 50SG953SK6 (Mitomycin)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Animals
MH  - *Drug Delivery Systems
MH  - Female
MH  - Gold
MH  - Hot Temperature
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Mice, Inbred BALB C
MH  - Mitomycin/*pharmacology
MH  - *Nanotubes
MH  - Neoplasms, Experimental/therapy
MH  - *Phototherapy
MH  - Stomach Neoplasms/*therapy
EDAT- 2016/12/07 06:00
MHDA- 2018/10/27 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2018/10/27 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
AID - 10.1039/c6nr06851k [doi]
PST - ppublish
SO  - Nanoscale. 2017 Jan 7;9(1):334-340. doi: 10.1039/c6nr06851k. Epub 2016 Dec 6.