PMID- 27922542
OWN - NLM
STAT- MEDLINE
DCOM- 20180306
LR  - 20181106
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 28
IP  - 4
DP  - 2017 Jun
TI  - Generalization of serotonin and dopamine ligands to the discriminative stimulus 
      effects of different doses of +/-3,4-methylenedioxymethamphetamine.
PG  - 245-254
LID - 10.1097/FBP.0000000000000282 [doi]
AB  - Studies that have attributed the discriminative stimulus effects of 
      +/-3,4-methylenedioxymethamphetamine (MDMA) to serotonergic mechanisms typically 
      use a relatively low training dose of 1.5 mg/kg. The role of serotonin in the 
      discriminative stimulus effects of higher doses of MDMA is, however, unknown. 
      Separate groups of rats were trained to discriminate MDMA (1.5 or 3.0 mg/kg) from 
      saline using a two-lever, food-reinforced drug-discrimination procedure. 
      Generalization tests were carried out with a range of serotonin and dopamine 
      ligands. Fluoxetine (0.3-3 mg/kg), clomipramine (1-10 mg/kg) and 
      meta-chlorophenylpiperazine (0.3-2 mg/kg) dose-dependently substituted for the 
      1.5 mg/kg MDMA stimulus, but not the 3.0 mg/kg MDMA stimulus. 8-OH-DPAT 
      (0.03-0.3 mg/kg) and RU-24969 (0.3-3 mg/kg) substituted for both the low-dose and 
      the high-dose MDMA stimulus. The generalization dose-effect curve produced by 
      2,5-dimethoxy-4-iodoamphetamine (0.3-3 mg/kg) was shifted to the right for the 
      3.0 mg/kg MDMA-trained group. Amphetamine (0.25 and 0.5 mg/kg) and apomorphine 
      (0.125 and 0.25 mg/kg) substituted for the 3.0 mg/kg, but not the 1.5 mg/kg MDMA 
      stimulus. The results suggest some differences in the role of serotonin and 
      dopamine in the discriminative stimulus effects of a low versus a higher dose of 
      MDMA.
FAU - Webster, Jeremy I
AU  - Webster JI
AD  - Faculty of Science, School of Psychology, Victoria University of Wellington, 
      Wellington, New Zealand.
FAU - Harper, David N
AU  - Harper DN
FAU - Schenk, Susan
AU  - Schenk S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Hallucinogens)
RN  - 0 (Ligands)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Discrimination Learning/*drug effects
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/administration & dosage/pharmacology
MH  - Ligands
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reinforcement Schedule
MH  - Serotonin/*metabolism
EDAT- 2016/12/07 06:00
MHDA- 2018/03/07 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2018/03/07 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
AID - 10.1097/FBP.0000000000000282 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2017 Jun;28(4):245-254. doi: 10.1097/FBP.0000000000000282.