PMID- 27922805
OWN - NLM
STAT- MEDLINE
DCOM- 20171120
LR  - 20171128
IS  - 1557-2501 (Electronic)
IS  - 1042-3931 (Linking)
VI  - 28
IP  - 12
DP  - 2016 Dec
TI  - Near-Infrared Spectroscopy Analysis of Coronary Chronic Total Occlusions.
PG  - 485-488
AB  - OBJECTIVE: To examine the presence and localization of lipid-core plaque (LCP) in 
      coronary vessels with chronic total occlusions (CTOs) using near-infrared 
      spectroscopy (NIRS). METHODS: NIRS imaging was performed after guidewire crossing 
      of the occlusion in 15 patients with CTOs. LCP was defined as >/=2 adjacent 2 mm 
      yellow blocks on the block chemogram. We also measured the maximum lipid-core 
      burden index (LCBI) in a 4 mm length of artery (maxLCBI4mm). Large LCP was 
      defined as maxLCBI4mm >/=500. RESULTS: Median patient age was 64 years 
      (interquartile range [IQR], 61-67 years) and all patients were men with high 
      prevalence of diabetes mellitus (64%) and prior coronary artery bypass graft 
      surgery (27%). The CTO target vessel was the right coronary artery (46%), left 
      anterior descending artery (27%), or circumflex artery (27%). Median occlusion 
      length was 35 mm (IQR, 30-50 mm). LCP was present in 11 of 15 CTO vessels (73%) 
      and a large LCP in 4 of 15 CTO vessels (27%). LCP was located at the proximal cap 
      in 6 CTOs (55%), the CTO body in 6 CTOs (55%), and the distal cap in 2 CTOs 
      (18%). The median overall LCBI and maxLCBI4mm were 145 (IQR, 79-243) and 415 
      (IQR, 267-505), respectively. All patients underwent successful stenting without 
      any complications. The 12-month incidence of in-stent restenosis and 
      target-lesion revascularization was 25%, and all patients who developed 
      restenosis had an LCP at baseline. CONCLUSIONS: LCPs are commonly encountered in 
      coronary CTO vessels, suggesting an active intraplaque atherosclerotic process. 
      The impact of LCP on postintervention outcomes requires further study.
FAU - Christakopoulos, Georgios E
AU  - Christakopoulos GE
FAU - Karacsonyi, Judit
AU  - Karacsonyi J
FAU - Danek, Barbara Anna
AU  - Danek BA
FAU - Karatasakis, Aris
AU  - Karatasakis A
FAU - Alame, Aya
AU  - Alame A
FAU - Kalsaria, Pratik
AU  - Kalsaria P
FAU - Mohammed, Atif
AU  - Mohammed A
FAU - Roesle, Michele
AU  - Roesle M
FAU - Rangan, Bavana V
AU  - Rangan BV
FAU - Banerjee, Subhash
AU  - Banerjee S
FAU - Brilakis, Emmanouil S
AU  - Brilakis ES
AD  - Minneapolis Heart Institute, 920 E. 28th Street #300, Minneapolis, MN 55407 USA. 
      esbrilakis@ gmail.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Invasive Cardiol
JT  - The Journal of invasive cardiology
JID - 8917477
RN  - 0 (Lipids)
SB  - IM
CIN - J Invasive Cardiol. 2016 Dec;28(12 ):489-490. PMID: 27922806
MH  - Aged
MH  - Comorbidity
MH  - Coronary Angiography/methods
MH  - Coronary Artery Bypass/*methods
MH  - *Coronary Occlusion/diagnosis/epidemiology/etiology
MH  - *Coronary Vessels/diagnostic imaging/pathology
MH  - Diabetes Mellitus/*epidemiology
MH  - Humans
MH  - Lipids/analysis
MH  - Male
MH  - Middle Aged
MH  - *Plaque, Atherosclerotic/chemistry/complications/diagnostic imaging
MH  - Preoperative Care/methods
MH  - Severity of Illness Index
MH  - Spectroscopy, Near-Infrared/*methods
MH  - Treatment Outcome
MH  - United States
EDAT- 2016/12/07 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/12/07 06:00 [entrez]
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PST - ppublish
SO  - J Invasive Cardiol. 2016 Dec;28(12):485-488.