PMID- 27922865
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20191210
IS  - 1536-0229 (Electronic)
IS  - 0363-9762 (Linking)
VI  - 42
IP  - 2
DP  - 2017 Feb
TI  - Additional Value of Early-Phase 18F-FP-CIT PET Image for Differential Diagnosis 
      of Atypical Parkinsonism.
PG  - e80-e87
LID - 10.1097/RLU.0000000000001474 [doi]
AB  - PURPOSE: Regional cerebral perfusion is coupled to metabolism in general. Early 
      perfusion dominant imaging using F-FP-CIT PET (pCIT) may provide complementary 
      information to delayed dopamine transporter dominant images. We investigated the 
      ability of pCIT to differentiate atypical Parkinson disorder from Parkinson 
      disease (PD) compared to FDG and the image quality for optimizing the acquisition 
      time. METHODS: Sixty-seven subjects [PD, 23 subjects; multiple system 
      atrophy-cerebellar type (MSA-C), 27 subjects; MSA-Parkinson type (MSA-P), 12 
      subjects; and progressive supranuclear palsy (PSP), 5 subjects] underwent 
      F-FP-CIT and FDG PET. Using dynamic PET data acquired during the first 10 minutes 
      after F-FP-CIT administration, we generated potential perfusion images of 0 to 5 
      (pCIT-5m), 0 to 7 (pCIT-7m), and 0 to 10 (pCIT-10m) minutes. We compared regional 
      uptake between groups in pCIT and FDG images and image quality among pCIT images 
      using visual, quantitative, or statistical parametric mapping analyses. RESULTS: 
      Regional cerebral uptake of pCITs correlated well to that of the FDG images (R > 
      0.5, all). Multiple system atrophy-cerebellar type and MSA-P groups show 
      different regional uptake patterns compared with PD group on pCITs in 
      quantitative and statistical parametric mapping analyses, analogous to FDG 
      images, but not in the PSP group. In visual analysis, concordance rates between 
      each pCIT and FDG image were high (92.3%-96.0%, regional; 86.2%-93.1%, 
      diagnostic), and there was no significant difference among pCITs. However, 
      pCIT-10m discriminated PSP better than others and showed higher signal-to-noise 
      ratio (P = 0.001). CONCLUSION: F-FP-CIT PETs with the first 10 minutes could be 
      useful for the differential diagnosis of atypical Parkinson disorder by providing 
      complementary FDG-like information to the dopamine transporter binding on 
      late-phase FP-CIT images.
FAU - Jin, Soyoung
AU  - Jin S
AD  - From the *Department of Nuclear Medicine, Nowon Eulji Medical Center, Eulji 
      University, Seoul, Korea; and Departments of daggerNuclear Medicine, and double daggerNeurology, 
      Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
FAU - Oh, Minyoung
AU  - Oh M
FAU - Oh, Seung Jun
AU  - Oh SJ
FAU - Oh, Jungsu S
AU  - Oh JS
FAU - Lee, Sang Ju
AU  - Lee SJ
FAU - Chung, Sun Ju
AU  - Chung SJ
FAU - Kim, Jae Seung
AU  - Kim JS
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Clin Nucl Med
JT  - Clinical nuclear medicine
JID - 7611109
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Tropanes)
RN  - 155797-99-2 (2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane)
SB  - IM
MH  - Aged
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*diagnostic imaging
MH  - *Positron-Emission Tomography
MH  - *Radiopharmaceuticals
MH  - Sensitivity and Specificity
MH  - *Tropanes
EDAT- 2016/12/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
AID - 10.1097/RLU.0000000000001474 [doi]
PST - ppublish
SO  - Clin Nucl Med. 2017 Feb;42(2):e80-e87. doi: 10.1097/RLU.0000000000001474.