PMID- 27923187
OWN - NLM
STAT- MEDLINE
DCOM- 20170531
LR  - 20180624
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 128
IP  - 1
DP  - 2017 Jan
TI  - Sleep EEG patterns in infants with congenital Zika virus syndrome.
PG  - 204-214
LID - S1388-2457(16)30648-4 [pii]
LID - 10.1016/j.clinph.2016.11.004 [doi]
AB  - OBJECTIVES: To describe sleep EEG patterns of neonates, and infants with 
      microcephaly due to congenital Zika virus (ZikV) syndrome. METHODS: A descriptive 
      case series of EEGs performed in a cohort of neonates with microcephaly monitored 
      from October 2015 to February 2016 at a University Hospital in Northeast Brazil. 
      Infants were investigated following an established protocol that includes EEG, 
      neuroimaging studies, PCR and specific antibodies for ZikV detection. RESULTS: 
      EEGs (n=37) from 37 infants were reviewed. Age at investigation varied from 1 to 
      5months (mean=2.6). Diffuse low voltage (n=7), background asymmetry (n=6) and 
      modified hypsarrhythmia with or without burst-suppression (n=11), were the main 
      background abnormalities identified. Interictal EEG abnormalities were identified 
      in 23 recordings (62%) and localized as focal frontal (n=8) or occipital (n=2) 
      spikes/sharp, multifocal spikes/sharp waves (n=13). Electrographic seizures 
      without clinical manifestation were identified in 4 recordings and characterized 
      as focal pseudo rhythmic pattern. Further findings were focal high amplitude slow 
      waves that were registered in the frontal (n=3) or occipital (n=1) regions. 
      CONCLUSIONS: Different types of EEG abnormalities were encountered with a 
      predominance of interictal epileptogenic activity and hypsarrhythmia. 
      SIGNIFICANCE: Sleep EEGs in congenital Zika virus syndrome are consistently 
      abnormal even in infants who have not yet developed epilepsy.
CI  - Copyright (c) 2016 International Federation of Clinical Neurophysiology. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Carvalho, Maria Durce Costa Gomes
AU  - Carvalho MDCG
AD  - UPE (University of Pernambuco), Recife, Brazil.
FAU - Miranda-Filho, Democrito de Barros
AU  - Miranda-Filho DB
AD  - UPE (University of Pernambuco), Recife, Brazil.
FAU - van der Linden, Vanessa
AU  - van der Linden V
AD  - Associacao de Assistencia a Crianca Deficiente (AACD), Recife, Brazil.
FAU - Sobral, Paula Fabiana
AU  - Sobral PF
AD  - UPE (University of Pernambuco), Recife, Brazil.
FAU - Ramos, Regina Coeli Ferreira
AU  - Ramos RCF
AD  - UPE (University of Pernambuco), Recife, Brazil.
FAU - Rocha, Maria Angela Wanderley
AU  - Rocha MAW
AD  - UPE (University of Pernambuco), Recife, Brazil.
FAU - Cordeiro, Marli Tenorio
AU  - Cordeiro MT
AD  - Department of Virology, Aggeu Magalhaes Research Center, Fiocruz-PE, Brazil.
FAU - de Alencar, Sarah Pinheiro
AU  - de Alencar SP
AD  - UPE (University of Pernambuco), Recife, Brazil.
FAU - Nunes, Magda Lahorgue
AU  - Nunes ML
AD  - School of Medicine - Pontificia Universidade Catolica do Rio Grande do Sul 
      (PUCRS) and Brain Institute of Rio Grande do Sul (BraIns), Porto Alegre, Brazil. 
      Electronic address: nunes@pucrs.br.
LA  - eng
PT  - Journal Article
DEP - 20161114
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
CIN - Clin Neurophysiol. 2017 Feb;128(2):289. PMID: 28042993
MH  - Cohort Studies
MH  - Electroencephalography/*methods
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Microcephaly/diagnosis/etiology/*physiopathology
MH  - *Sleep/physiology
MH  - Sleep Wake Disorders/diagnosis/*physiopathology
MH  - *Zika Virus
MH  - Zika Virus Infection/complications/diagnosis/*physiopathology
OTO - NOTNLM
OT  - EEG
OT  - Microcephaly
OT  - Newborns
OT  - Zika virus
EDAT- 2016/12/07 06:00
MHDA- 2017/06/01 06:00
CRDT- 2016/12/07 06:00
PHST- 2016/08/14 00:00 [received]
PHST- 2016/11/01 00:00 [revised]
PHST- 2016/11/04 00:00 [accepted]
PHST- 2016/12/07 06:00 [pubmed]
PHST- 2017/06/01 06:00 [medline]
PHST- 2016/12/07 06:00 [entrez]
AID - S1388-2457(16)30648-4 [pii]
AID - 10.1016/j.clinph.2016.11.004 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2017 Jan;128(1):204-214. doi: 10.1016/j.clinph.2016.11.004. 
      Epub 2016 Nov 14.