PMID- 27923643
OWN - NLM
STAT- MEDLINE
DCOM- 20170201
LR  - 20191210
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 262
DP  - 2017 Jan 25
TI  - Anthraquinone derivative exerted hormetic effect on the apoptosis in 
      oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 
      signaling pathway.
PG  - 1-11
LID - S0009-2797(16)30663-9 [pii]
LID - 10.1016/j.cbi.2016.12.001 [doi]
AB  - There were accumulated evidences that agents may attenuate neurological disorders 
      through a hormetic effect. This study was designed to investigate hormetic effect 
      of BME on the oxygen-glucose deprivation (OGD)-induced mitochondrial apoptosis in 
      NGF-differentiated PC12 cells. The effect of BME on the intracellular reactive 
      oxygen species (iROS) formation and pro-survival signals mediated by ERK and Akt 
      as well as transcription factor nuclear factor-erythroid 2 p45-related factor 2 
      (Nrf2) pathways was also determined. The present results showed that, at low 
      concentrations, pretreatment with BME triggered stress response by causing ROS 
      production, then, activated survival-promoting signals via ERK and Akt activated 
      Nrf2/HO-1 signaling pathway, resulting in decrease in cytotoxicity induced by the 
      OGD. It may be accepted that mild pretreatment with BME stimulated transient and 
      moderate ROS production, but activated hormetic signals and induced stress 
      responsive genes. In contrast, high concentrations of BME displayed toxic action 
      due to massive ROS production. These results suggested that the effect of BME on 
      the OGD-induced PC12 cells may be hormetic mechanism including induction of 
      oxidative stress and subsequent activation of stress response gene expression.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Liu, Lu
AU  - Liu L
AD  - Key Laboratory of Natural Medicine and Immune Engineering, Henan University, 
      Kaifeng 475001, People's Republic of China.
FAU - Huang, Weiwei
AU  - Huang W
AD  - Key Laboratory of Natural Medicine and Immune Engineering, Henan University, 
      Kaifeng 475001, People's Republic of China.
FAU - Wang, Jianhong
AU  - Wang J
AD  - Key Laboratory of Natural Medicine and Immune Engineering, Henan University, 
      Kaifeng 475001, People's Republic of China.
FAU - Song, Huiling
AU  - Song H
AD  - Key Laboratory of Natural Medicine and Immune Engineering, Henan University, 
      Kaifeng 475001, People's Republic of China.
FAU - Cen, Juan
AU  - Cen J
AD  - Key Laboratory of Natural Medicine and Immune Engineering, Henan University, 
      Kaifeng 475001, People's Republic of China. Electronic address: 
      cenjuan@henu.edu.cn.
FAU - Ji, Biansheng
AU  - Ji B
AD  - Key Laboratory of Natural Medicine and Immune Engineering, Henan University, 
      Kaifeng 475001, People's Republic of China. Electronic address: 
      jibiansheng2005@126.com.
LA  - eng
PT  - Journal Article
DEP - 20161205
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Anthraquinones)
RN  - 0 (Chromones)
RN  - 0 (Morpholines)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Phosphoinositide-3 Kinase Inhibitors)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Reactive Oxygen Species)
RN  - 31M2U1DVID (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.3.1.16 (Mitochondrial Trifunctional Protein)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Anthraquinones/chemistry/*toxicity
MH  - Apoptosis/*drug effects
MH  - Blotting, Western
MH  - Catalase/analysis
MH  - *Cell Hypoxia
MH  - Cell Survival/drug effects
MH  - Chromones/pharmacology
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Glucose/pharmacology
MH  - Heme Oxygenase-1/metabolism
MH  - Mitochondria/drug effects/metabolism
MH  - Mitochondrial Trifunctional Protein/drug effects
MH  - Morpholines/pharmacology
MH  - NF-E2-Related Factor 2/antagonists & inhibitors/genetics/metabolism
MH  - Oxidative Stress/drug effects
MH  - PC12 Cells
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphoinositide-3 Kinase Inhibitors
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - RNA Interference
MH  - RNA, Small Interfering/metabolism
MH  - Rats
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction/*drug effects
MH  - Superoxide Dismutase/analysis
OTO - NOTNLM
OT  - BME
OT  - Hormetic effect
OT  - Nrf2
OT  - Oxygen-glucose deprivation
OT  - PC12 cells
EDAT- 2016/12/08 06:00
MHDA- 2017/02/02 06:00
CRDT- 2016/12/08 06:00
PHST- 2016/08/10 00:00 [received]
PHST- 2016/11/24 00:00 [revised]
PHST- 2016/12/02 00:00 [accepted]
PHST- 2016/12/08 06:00 [pubmed]
PHST- 2017/02/02 06:00 [medline]
PHST- 2016/12/08 06:00 [entrez]
AID - S0009-2797(16)30663-9 [pii]
AID - 10.1016/j.cbi.2016.12.001 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2017 Jan 25;262:1-11. doi: 10.1016/j.cbi.2016.12.001. Epub 
      2016 Dec 5.