PMID- 27924671
OWN - NLM
STAT- MEDLINE
DCOM- 20180112
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 58
IP  - 8
DP  - 2017 Aug
TI  - The effect of the additional cytogenetic abnormalities on major molecular 
      response and BCR-ABL kinase domain mutations in long-term follow-up chronic 
      myeloid leukemia patients, a cross sectional study.
PG  - 1958-1962
LID - 10.1080/10428194.2016.1265112 [doi]
AB  - The aim of the study was to examine the relation between additional chromosomal 
      aberrations (ACAs) with major molecular response (MMR) and BCR-ABL kinase domain 
      (KD) mutations in the long-term follow-up of the chronic myeloid leukemia (CML) 
      disease. The study design was cross-sectional observational and used the CML 
      patients' data of Izmir Ataturk Education and Research Hospital from 2011 to 
      2015. Conventional cytogenetic, fluorescence in situ hybridization (FISH), 
      quantitative real-time polymerase chain reaction (RQ-PCR) test results from 89 
      CML patients' and pyrosequencing analysis results from 17 patients' were set up 
      for comparison analysis. The chi-square test was used in statistical analysis of 
      the experimental data. There were no statistically significant correlations 
      between ACAs and MMR (p = .361, p > .05) groups or BCR-ABL KD mutations 
      (p = .576, p > .05) groups observed in the study. This study has revealed that 
      MMR and BCR-ABL KD mutations did not correlate with ACAs.
FAU - Savasoglu, Kaan
AU  - Savasoglu K
AD  - a Department of Genetic , Izmir Ataturk Education and Research Hospital , Izmir , 
      Turkey.
FAU - Payzin, Kadriye Bahriye
AU  - Payzin KB
AD  - b Department of Hematology , Izmir Ataturk Education and Research Hospital , 
      Izmir , Turkey.
FAU - Ozdemirkiran, Fusun
AU  - Ozdemirkiran F
AD  - b Department of Hematology , Izmir Ataturk Education and Research Hospital , 
      Izmir , Turkey.
FAU - Subasioglu, Asli
AU  - Subasioglu A
AD  - a Department of Genetic , Izmir Ataturk Education and Research Hospital , Izmir , 
      Turkey.
FAU - Yilmaz, Asu Fergun
AU  - Yilmaz AF
AD  - b Department of Hematology , Izmir Ataturk Education and Research Hospital , 
      Izmir , Turkey.
LA  - eng
PT  - Journal Article
DEP - 20161207
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
CIN - Leuk Lymphoma. 2017 Oct;58(10):2516-2517. PMID: 28278707
MH  - Adult
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Cross-Sectional Studies
MH  - Drug Resistance, Neoplasm/genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug 
      therapy/*genetics/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - *Mutation
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Protein Interaction Domains and Motifs/*genetics
MH  - Protein Kinase Inhibitors/pharmacology/therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - CML
OT  - TKI
OT  - cytogenetic abnormalities
OT  - prognosis
OT  - quantitative real-time PCR
EDAT- 2016/12/08 06:00
MHDA- 2018/01/13 06:00
CRDT- 2016/12/08 06:00
PHST- 2016/12/08 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PHST- 2016/12/08 06:00 [entrez]
AID - 10.1080/10428194.2016.1265112 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2017 Aug;58(8):1958-1962. doi: 10.1080/10428194.2016.1265112. Epub 
      2016 Dec 7.