PMID- 27928120
OWN - NLM
STAT- MEDLINE
DCOM- 20170602
LR  - 20170602
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 62
IP  - 5
DP  - 2016
TI  - Effect of Long-Term Proton Pump Inhibitor Therapy on Nutritional Status in 
      Elderly Hospitalized Patients.
PG  - 330-334
AB  - The purpose was to investigate the association between proton pump inhibitor 
      (PPI) therapy and nutritional status in elderly hospitalized patients. 
      Participants were 190 elderly patients admitted to the long-term care wards, 
      convalescence rehabilitation wards, and community integrated care wards in 
      January 2015. Nutritional status was assessed using the mini nutritional 
      assessment short-form (MNA-SF). The PPI use group was compared with the PPI 
      non-use group regarding nutrition status. Logistic regression analysis was used 
      to examine whether the period of PPI therapy was associated independently with 
      malnutrition following adjustment for covariates including gender, age, and serum 
      albumin level. Forty-one patients were male (22%) and 149 patients were female 
      (78%), with a mean age of 85.4+/-8.4. Fifty-three patients (28%) took PPIs (with a 
      median prescription period of 91 d, ranging from 51 to 227). With a MNA-SF score 
      of 7 points or lower designated as malnutrition, there was no significant 
      difference in nutritional status between the PPI and non-PPI groups (p=0.172). 
      The median MNA-SF scores in the PPI and non-PPI groups were 9 vs 7 points, 
      respectively. Logistic regression analysis showed that long-term PPI therapy 
      (odds ratio, 0.994; 95% confidence interval 0.990-0.999) was significantly 
      associated with improved nutritional status. The presence or absence of PPI 
      therapy is not associated with malnutrition in elderly hospitalized patients. 
      Longer-term PPI therapy may improve nutritional status.
FAU - Nakamichi, Mariko
AU  - Nakamichi M
AD  - Department of Pharmacy, Haradoi Hospital.
FAU - Wakabayashi, Hidetaka
AU  - Wakabayashi H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Body Weight
MH  - Dose-Response Relationship, Drug
MH  - Energy Intake
MH  - Female
MH  - Geriatric Assessment
MH  - Hospitalization
MH  - Humans
MH  - Inpatients
MH  - Logistic Models
MH  - Male
MH  - Malnutrition/*epidemiology
MH  - Nutrition Assessment
MH  - *Nutritional Status
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Serum Albumin/metabolism
MH  - Time Factors
EDAT- 2016/12/09 06:00
MHDA- 2017/06/03 06:00
CRDT- 2016/12/09 06:00
PHST- 2016/12/09 06:00 [entrez]
PHST- 2016/12/09 06:00 [pubmed]
PHST- 2017/06/03 06:00 [medline]
AID - 10.3177/jnsv.62.330 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2016;62(5):330-334. doi: 10.3177/jnsv.62.330.