PMID- 27930591
OWN - NLM
STAT- MEDLINE
DCOM- 20170215
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 49
DP  - 2016 Dec
TI  - Weight loss before a diagnosis of type 2 diabetes mellitus is a risk factor for 
      diabetes complications.
PG  - e5618
LID - 10.1097/MD.0000000000005618 [doi]
LID - e5618
AB  - Our goal was to investigate the relationship between weight loss before a 
      diagnosis of type 2 diabetes mellitus (T2DM) and diabetic complications among 
      hospitalized patients with T2DM.We conducted a cross-sectional study and 
      evaluated 347 and 642 hospitalized patients with T2DM who experienced and did not 
      experienced weight loss before T2DM diagnosis, respectively. We used propensity 
      score matching to reduce the confounding bias between the groups. In addition, a 
      logistic regression analysis of the matched data was performed to evaluate the 
      risk of diabetic complications.A total of 339 patients who experienced weight 
      loss were matched to 339 patients who did not experience weight loss. After 
      adjusting for age, gender, origin, occupation, smoking history, alcohol use, and 
      duration of diabetes, the logistic regression analysis showed that compared with 
      patients who did not experience weight loss, patients who lost </=5 kg had a higher 
      risk of diabetic nephropathy (DN) (odds ratio [OR]: 2.05, 95% confidence interval 
      [CI]: 1.35-3.10) and diabetic retinopathy (OR: 1.79, 95% CI: 1.11-2.87). However, 
      we did not observe a dose-response relationship in terms of weight loss.We found 
      that weight loss before a diagnosis of T2DM might serve as a risk factor for DN 
      and diabetic retinopathy. Our findings demonstrate that we should strengthen the 
      management and prevention of complications in patients who experience weight loss 
      of </=5 kg prior to a T2DM diagnosis, particularly those who are centrally obese.
FAU - Yang, Shanshan
AU  - Yang S
AD  - Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, State 
      Key Laboratory of Kidney Disease, Chinese PLA General Hospital, Beijing Jinan 
      Military Area CDC, Jinan, Shandong Department of Nephrology and Endocrinology, 
      PLA 148th Hospital, Zibo, China.
FAU - Wang, Shuang
AU  - Wang S
FAU - Yang, Bo
AU  - Yang B
FAU - Zheng, Jinliang
AU  - Zheng J
FAU - Cai, Yuping
AU  - Cai Y
FAU - Yang, Zhengguo
AU  - Yang Z
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - China
MH  - Cross-Sectional Studies
MH  - Databases, Factual
MH  - Diabetes Complications/diagnosis/*epidemiology
MH  - Diabetes Mellitus, Type 2/*diagnosis/epidemiology/therapy
MH  - Diabetic Angiopathies/diagnosis/epidemiology
MH  - Diabetic Nephropathies/diagnosis/epidemiology
MH  - Diabetic Retinopathy/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Prediabetic State
MH  - Prevalence
MH  - Propensity Score
MH  - Reference Values
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - *Weight Loss
PMC - PMC5266063
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2016/12/09 06:00
MHDA- 2017/02/16 06:00
PMCR- 2016/12/09
CRDT- 2016/12/09 06:00
PHST- 2016/12/09 06:00 [entrez]
PHST- 2016/12/09 06:00 [pubmed]
PHST- 2017/02/16 06:00 [medline]
PHST- 2016/12/09 00:00 [pmc-release]
AID - 00005792-201612060-00088 [pii]
AID - MD-D-16-05374 [pii]
AID - 10.1097/MD.0000000000005618 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Dec;95(49):e5618. doi: 10.1097/MD.0000000000005618.