PMID- 27931298
OWN - NLM
STAT- MEDLINE
DCOM- 20170220
LR  - 20190609
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 37
IP  - 6
DP  - 2016 Nov
TI  - Utility of component diagnostic testing in guiding oral food challenges to milk 
      and egg.
PG  - 439-442
AB  - BACKGROUND: Food allergies affect up to 8% of children, and milk and egg 
      allergies are the most common triggers. Accurately diagnosing these food 
      allergies is important to prevent allergic reactions and to avoid unnecessary 
      dietary restrictions. However, positive skin-prick tests and detectable levels of 
      serum food specific immunoglobulin E (IgE) alone may not be diagnostic for food 
      allergy. Advances in the identification of relevant allergens and the development 
      of recombinant proteins now allow assessment of IgE binding to individual 
      proteins within a food. Component-resolved diagnostics (CRD) have the potential 
      to provide more accurate assessments of clinical reactivity to food allergens. 
      OBJECTIVE: To examine the available data for CRD for milk and egg allergies. 
      METHODS: This review discussed studies that evaluated the utility of CRD for 
      guiding decisions about food challenges for milk and egg. RESULTS: Results of 
      studies indicated that CRD may offer increased specificity, but sensitivity was 
      lacking when compared with standard skin-prick testing and measurement of serum 
      food specific IgE levels. CONCLUSION: The role of CRD in the diagnosis and 
      management of milk and egg allergies is not well established at this time. 
      Further studies are needed to explore the diagnostic value of CRD for milk and 
      egg allergies.
FAU - Wang, Julie
AU  - Wang J
AD  - Division of Allergy and Immunology, Department of Pediatrics, Icahn School of 
      Medicine at Mount Sinai, New York, New York, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*administration & dosage/*immunology
MH  - Animals
MH  - Clinical Decision-Making
MH  - Egg Hypersensitivity/*diagnosis/*immunology
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - *Immunologic Tests
MH  - *Milk
MH  - Milk Hypersensitivity/*diagnosis/*immunology
MH  - *Ovum
EDAT- 2016/12/10 06:00
MHDA- 2017/08/18 06:00
CRDT- 2016/12/10 06:00
PHST- 2016/12/10 06:00 [entrez]
PHST- 2016/12/10 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
AID - 10.2500/aap.2016.37.3997 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2016 Nov;37(6):439-442. doi: 10.2500/aap.2016.37.3997.