PMID- 27932168
OWN - NLM
STAT- MEDLINE
DCOM- 20170405
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 48
IP  - 9
DP  - 2016 Nov
TI  - Spindle Cell Lipoma in an End-Stage Renal Allograft: Case Report.
PG  - 3145-3148
LID - S0041-1345(16)30523-1 [pii]
LID - 10.1016/j.transproceed.2016.09.001 [doi]
AB  - BACKGROUND: Spindle cell lipoma is an uncommon variant of lipoma and usually 
      occurs as a solitary, subcutaneous, and well circumscribed lesion in the 
      posterior neck, shoulders, and back of older men. Primary renal lipomas are 
      rarely reported. Spindle cell lipoma in the kidney has not been previously 
      described in the literature. CASE REPORT: A 60-year-old Chinese man suffered 
      graft failure 10 years after living related donor kidney transplantation. During 
      cancer surveillance, he was found to have a mass in the renal allograft, which 
      increased in size and was suspicious for renal cell carcinoma on computerized 
      tomographic scan. The patient underwent renal graft explantation. Grossly, the 
      kidney was atrophic, containing a 6.5 cm yellowish solid lesion without 
      hemorrhage and necrosis in the renal sinus fat. Microscopically, the lesion was 
      composed of variably sized adipocytes and cellular areas of bland spindle cells 
      with no cytologic atypia. There were prominent slender blood vessels within the 
      lesion, along with focal myxoid change as well as scattered mast cells and 
      inflammatory cells. Lipoblasts were not identified. The spindle cells were 
      positive for CD34 and negative for Melan-A, HMB45, S100, and SMA. Pax-2 stain was 
      nonspecific. MDM2 amplification by means of fluorescence in situ hybridization 
      (FISH) and overexpression by immunohistochemistry were negative. The Ki-67 
      proliferation index was <1%. Interphase FISH revealed loss of 13q and 16q in the 
      tumor. CONCLUSIONS: Renal spindle cell lipoma is a rare benign tumor. 
      Angiomyolipoma and well differentiated liposarcoma are the main differential 
      diagnoses. Immunohistochemistry and cytogenetic techniques are helpful in 
      differentiating it from malignant entities.
CI  - Copyright A(c) 2016 Elsevier Inc. All rights reserved.
FAU - Zhao, Z
AU  - Zhao Z
AD  - Department of Anatomical Pathology, Division of Pathology, Singapore General 
      Hospital, Singapore.
FAU - Selvarajan, S
AU  - Selvarajan S
AD  - Department of Anatomical Pathology, Division of Pathology, Singapore General 
      Hospital, Singapore.
FAU - Tiong, A L S
AU  - Tiong AL
AD  - Department of Molecular Pathology, Division of Pathology, Singapore General 
      Hospital, Singapore.
FAU - Lim, T H
AU  - Lim TH
AD  - Department of Molecular Pathology, Division of Pathology, Singapore General 
      Hospital, Singapore.
FAU - Khor, L Y
AU  - Khor LY
AD  - Department of Anatomical Pathology, Division of Pathology, Singapore General 
      Hospital, Singapore. Electronic address: khor.li.yan@singhealth.com.sg.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - Diagnosis, Differential
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney Neoplasms/diagnosis/*pathology
MH  - *Kidney Transplantation
MH  - Lipoma/diagnosis/*pathology
MH  - Male
MH  - Middle Aged
MH  - Transplantation, Homologous
EDAT- 2016/12/10 06:00
MHDA- 2017/04/06 06:00
CRDT- 2016/12/10 06:00
PHST- 2016/08/12 00:00 [received]
PHST- 2016/09/01 00:00 [accepted]
PHST- 2016/12/10 06:00 [entrez]
PHST- 2016/12/10 06:00 [pubmed]
PHST- 2017/04/06 06:00 [medline]
AID - S0041-1345(16)30523-1 [pii]
AID - 10.1016/j.transproceed.2016.09.001 [doi]
PST - ppublish
SO  - Transplant Proc. 2016 Nov;48(9):3145-3148. doi: 
      10.1016/j.transproceed.2016.09.001.