PMID- 27932337 OWN - NLM STAT- MEDLINE DCOM- 20171127 LR - 20220410 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 6 IP - 12 DP - 2016 Dec 8 TI - Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS). PG - e011458 LID - 10.1136/bmjopen-2016-011458 [doi] LID - e011458 AB - OBJECTIVES: The aim of this study was to develop a critical appraisal (CA) tool that addressed study design and reporting quality as well as the risk of bias in cross-sectional studies (CSSs). In addition, the aim was to produce a help document to guide the non-expert user through the tool. DESIGN: An initial scoping review of the published literature and key epidemiological texts was undertaken prior to the formation of a Delphi panel to establish key components for a CA tool for CSSs. A consensus of 80% was required from the Delphi panel for any component to be included in the final tool. RESULTS: An initial list of 39 components was identified through examination of existing resources. An international Delphi panel of 18 medical and veterinary experts was established. After 3 rounds of the Delphi process, the Appraisal tool for Cross-Sectional Studies (AXIS tool) was developed by consensus and consisted of 20 components. A detailed explanatory document was also developed with the tool, giving expanded explanation of each question and providing simple interpretations and examples of the epidemiological concepts being examined in each question to aid non-expert users. CONCLUSIONS: CA of the literature is a vital step in evidence synthesis and therefore evidence-based decision-making in a number of different disciplines. The AXIS tool is therefore unique and was developed in a way that it can be used across disciplines to aid the inclusion of CSSs in systematic reviews, guidelines and clinical decision-making. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. FAU - Downes, Martin J AU - Downes MJ AD - Centre for Applied Health Economics, School of Medicine, Griffith University, Meadowbrook, Queensland, Australia. FAU - Brennan, Marnie L AU - Brennan ML AD - Centre for Evidence-based Veterinary Medicine, The University of Nottingham, Loughborough, UK. FAU - Williams, Hywel C AU - Williams HC AD - Centre of Evidence Based Dermatology, The University of Nottingham, Nottingham, UK. FAU - Dean, Rachel S AU - Dean RS AD - Centre for Evidence-based Veterinary Medicine, The University of Nottingham, Loughborough, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20161208 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Bias MH - Clinical Decision-Making MH - Consensus MH - Cross-Sectional Studies/*standards MH - Delphi Technique MH - Evidence-Based Medicine/*methods MH - Humans MH - Research Design/*standards PMC - PMC5168618 OTO - NOTNLM OT - Critical appraisal OT - Cross sectional studies OT - Delphi OT - Evidence-based Healthcare COIS- Conflicts of Interest: None declared. EDAT- 2016/12/10 06:00 MHDA- 2017/11/29 06:00 PMCR- 2016/12/08 CRDT- 2016/12/10 06:00 PHST- 2016/12/10 06:00 [entrez] PHST- 2016/12/10 06:00 [pubmed] PHST- 2017/11/29 06:00 [medline] PHST- 2016/12/08 00:00 [pmc-release] AID - bmjopen-2016-011458 [pii] AID - 10.1136/bmjopen-2016-011458 [doi] PST - epublish SO - BMJ Open. 2016 Dec 8;6(12):e011458. doi: 10.1136/bmjopen-2016-011458.