PMID- 27932554
OWN - NLM
STAT- MEDLINE
DCOM- 20181226
LR  - 20181226
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 68
IP  - 8
DP  - 2017 Sep
TI  - Inflammatory Cytokine Levels After Endovascular Therapy in Patients With 
      Peripheral Artery Disease.
PG  - 734-740
LID - 10.1177/0003319716682122 [doi]
AB  - We evaluated the impact of endovascular therapy (EVT) on inflammatory cytokine 
      levels and its relationship with in-stent restenosis in patients with peripheral 
      artery disease. The study prospectively enrolled 35 patients with intermittent 
      claudication who underwent EVT of the iliofemoral artery. Levels of interleukin 6 
      (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha 
      (TNF-alpha) were measured using enzyme-linked immunosorbent assay before and at 2 
      hours, 4 hours, and 3 months after EVT. All cytokine levels increased 
      significantly after EVT (IL-6 [pg/mL]: from 1.51 [0.84-1.93] before EVT to 6.97 
      [4.05-20.41] at 2 hours and 13.29 [4.57-31.88] at 4 hours; MCP-1 [pg/mL]: from 
      326.65 [265.60-406.55] before EVT to 411.18 [341.21-566.27] at 2 hours and 519.36 
      [383.58-644.85] at 4 hours; TNF-alpha [pg/mL]: from 1.08 [0.77-1.29] before EVT to 
      1.25 [0.94-1.81] at 2 hours and 1.27 [0.95-1.59] at 4 hours, all P < .001). 
      However, cytokine levels did not differ significantly between lesions with and 
      without in-stent restenosis. Overall, our results suggest that EVT significantly 
      increases IL-6, MCP-1, and TNF-alpha levels in the ischemic leg, but this effect is 
      not associated with a higher rate of in-stent restenosis.
FAU - Ueki, Yasushi
AU  - Ueki Y
AD  - 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, 
      Matsumoto, Nagano, Japan.
FAU - Miura, Takashi
AU  - Miura T
AD  - 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, 
      Matsumoto, Nagano, Japan.
FAU - Miyashita, Yusuke
AU  - Miyashita Y
AD  - 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, 
      Matsumoto, Nagano, Japan.
FAU - Ebisawa, Souichiro
AU  - Ebisawa S
AD  - 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, 
      Matsumoto, Nagano, Japan.
FAU - Motoki, Hirohiko
AU  - Motoki H
AD  - 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, 
      Matsumoto, Nagano, Japan.
FAU - Izawa, Atsushi
AU  - Izawa A
AD  - 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, 
      Matsumoto, Nagano, Japan.
FAU - Koyama, Jun
AU  - Koyama J
AD  - 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, 
      Matsumoto, Nagano, Japan.
FAU - Ikeda, Uichi
AU  - Ikeda U
AD  - 1 Department of Cardiovascular Medicine, Shinshu University, School of Medicine, 
      Matsumoto, Nagano, Japan.
LA  - eng
PT  - Journal Article
DEP - 20161208
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CIN - Angiology. 2017 Sep;68(8):741. PMID: 28359157
MH  - Aged
MH  - Ankle Brachial Index
MH  - Chemokine CCL2/*blood
MH  - *Endovascular Procedures
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Graft Occlusion, Vascular/*blood
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Peripheral Arterial Disease/diagnostic imaging/*therapy
MH  - Prospective Studies
MH  - *Stents
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/*blood
OTO - NOTNLM
OT  - cytokine
OT  - endovascular therapy
OT  - interleukin 6
OT  - peripheral artery disease
EDAT- 2016/12/10 06:00
MHDA- 2018/12/27 06:00
CRDT- 2016/12/10 06:00
PHST- 2016/12/10 06:00 [pubmed]
PHST- 2018/12/27 06:00 [medline]
PHST- 2016/12/10 06:00 [entrez]
AID - 0003319716682122 [pii]
AID - 10.1177/0003319716682122 [doi]
PST - ppublish
SO  - Angiology. 2017 Sep;68(8):734-740. doi: 10.1177/0003319716682122. Epub 2016 Dec 
      8.