PMID- 27932984
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 7
DP  - 2016
TI  - Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in 
      Mice with Experimental Colitis.
PG  - 455
LID - 455
AB  - Dendritic cells (DCs) play a pivotal role as initiators in the pathogenesis of 
      inflammatory bowel disease and are regulated by the JAK/STAT/SOCS signaling 
      pathway. As a potent anti-inflammatory compound, curcumin represents a viable 
      treatment alternative or adjunctive therapy in the management of chronic 
      inflammatory bowel disease (IBD). The mechanism of curcumin treated IBD on DCs is 
      not completely understood. In the present study, we explored the mechanism of 
      curcumin treated experimental colitis by observing activation of DCs via 
      JAK/STAT/SOCS signaling pathway in colitis mice. Experimental colitis was induced 
      by 2, 4, 6-trinitrobenzene sulfonic acid. After 7 days treatment with curcumin, 
      its therapeutic effect was verified by decreased colonic weight, histological 
      scores, and remitting pathological injury. Meanwhile, the levels of major 
      histocompatibility complex class II and DC costimulatory molecules (CD83, CD28, 
      B7-DC, CD40, CD40 L, and TLR2) were inhibited and followed the up-regulated 
      levels of IL-4, IL-10, and IFN-gamma, and down-regulated GM-CSF, IL-12p70, IL-15, 
      IL-23, and TGF-beta1. A key finding was that the phosphorylation of the three 
      members (JAK2, STAT3, and STAT6) of the JAK/STAT/SOCS signaling pathway was 
      inhibited, and the three downstream proteins (SOCS1, SOCS3, and PIAS3) from this 
      pathway were highly expressed. In conclusion, curcumin suppressed the activation 
      of DCs by modulating the JAK/STAT/SOCS signaling pathway to restore immunologic 
      balance to effectively treat experimental colitis.
FAU - Zhao, Hai-Mei
AU  - Zhao HM
AD  - School of Basic Medical Sciences, Jiangxi University of Traditional Chinese 
      Medicine Nanchang, China.
FAU - Xu, Rong
AU  - Xu R
AD  - Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine 
      Nanchang, China.
FAU - Huang, Xiao-Ying
AU  - Huang XY
AD  - Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi 
      University of Traditional Chinese Medicine Nanchang, China.
FAU - Cheng, Shao-Min
AU  - Cheng SM
AD  - School of Basic Medical Sciences, Jiangxi University of Traditional Chinese 
      Medicine Nanchang, China.
FAU - Huang, Min-Fang
AU  - Huang MF
AD  - Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine 
      Nanchang, China.
FAU - Yue, Hai-Yang
AU  - Yue HY
AD  - Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine 
      Nanchang, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine 
      Nanchang, China.
FAU - Zou, Yong
AU  - Zou Y
AD  - Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine 
      Nanchang, China.
FAU - Lu, Ai-Ping
AU  - Lu AP
AD  - School of Chinese Medicine, Hong Kong Baptist University Kowloon Tong, China.
FAU - Liu, Duan-Yong
AU  - Liu DY
AD  - Science and Technology College, Jiangxi University of Traditional Chinese 
      Medicine Nanchang, China.
LA  - eng
PT  - Journal Article
DEP - 20161125
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC5122716
OTO - NOTNLM
OT  - JAK/STAT/SOCS signal
OT  - costimulatory molecules
OT  - curcumin
OT  - dendritic cell
OT  - experimental colitis
EDAT- 2016/12/10 06:00
MHDA- 2016/12/10 06:01
PMCR- 2016/11/25
CRDT- 2016/12/10 06:00
PHST- 2016/08/28 00:00 [received]
PHST- 2016/11/14 00:00 [accepted]
PHST- 2016/12/10 06:00 [entrez]
PHST- 2016/12/10 06:00 [pubmed]
PHST- 2016/12/10 06:01 [medline]
PHST- 2016/11/25 00:00 [pmc-release]
AID - 10.3389/fphar.2016.00455 [doi]
PST - epublish
SO  - Front Pharmacol. 2016 Nov 25;7:455. doi: 10.3389/fphar.2016.00455. eCollection 
      2016.