PMID- 27933513
OWN - NLM
STAT- MEDLINE
DCOM- 20180615
LR  - 20181113
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 23
IP  - 9
DP  - 2017 Sep
TI  - Effect of Yiqi Tongyang Decoction () on blood T cell subsets in patients with 
      chronic immune thrombocytopenia.
PG  - 709-713
LID - 10.1007/s11655-016-2278-7 [doi]
AB  - OBJECTIVE: To measure the proportions of blood T cell subsets, Th1, Th2, Th17, 
      Th22, and Treg cells, and other parameters in patients with chronic immune 
      thrombocytopenia (CITP) before and after treatment with Yiqi Tongyang Decoction 
      (, YTD) to explore T cell status of patients with CITP, and to defifine the 
      mechanism of action of YTD. METHODS: The changes in peripheral blood T lymphocyte 
      subsets, and those of Th1, Th2, Th17, Th22, and Treg cells in 30 patients with 
      CITP (22 females and 8 males) were analyzed using multiparametric flflow 
      cytometry before and after treatment with YTD for 6 months, and 26 healthy 
      volunteers (14 males and 12 females) acted as a control. T-box expressed in 
      T-cells (T-bet) and GATA binding protein 3 (GATA-3) mRNA levels in patients and 
      controls were analyzed using real-time reverse transcription-polymerase chain 
      reaction. RESULTS: The proportions of Th1, Th17, Th22, Th1/Th2, and Th17/Treg 
      cells increased in the peripheral blood of patients with CITP compared to those 
      in controls before YTD therapy (P<0.05). Th1 cell numbers and the Th1/Th2 ratio 
      fell in the treated patients with CITP to approximate the values of the control 
      group (P>0.05). Th17 cell numbers and the Th17/Treg ratio also decreased in the 
      treatment group (P<0.05), but not to the levels of the controls. The number of 
      Treg cells in the peripheral blood of patients with CITP before treatment was 
      lower than that in the control group (P<0.05), but increased after YTD treatment 
      P<0.05), but not to the level of controls. T-bet and GATA-3 mRNA levels in 
      peripheral blood were initially higher in patients before treatment than controls 
      (P<0.05), but decreased after YTD therapy (P<0.05). CONCLUSIONS: Imbalances in T 
      lymphocyte levels, particularly those of Th1/Th2 and Th17/Treg cells, play 
      important roles in the pathogenesis of CITP. YTD effificiently regulated the 
      dynamics of Th1/Th2 and Th17/Treg equilibria.
FAU - Yang, Xiu-Peng
AU  - Yang XP
AD  - Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, 100091, China.
FAU - Ma, Rou
AU  - Ma R
AD  - Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, 100091, China.
FAU - Yang, Xiao-Hong
AU  - Yang XH
AD  - Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, 100091, China.
FAU - Zhu, Hui-Lan
AU  - Zhu HL
AD  - Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, 100091, China.
FAU - Xu, Yong-Gang
AU  - Xu YG
AD  - Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, 100091, China. xyg312@163.com.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20161209
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (T-Box Domain Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Female
MH  - GATA3 Transcription Factor/genetics/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Purpura, Thrombocytopenic, Idiopathic/*blood/*drug therapy/genetics/immunology
MH  - RNA, Messenger/genetics/metabolism
MH  - T-Box Domain Proteins/metabolism
MH  - T-Lymphocyte Subsets/drug effects/*immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Chinese medicine
OT  - GATA binding protein 3
OT  - T-box expressed in T-cells
OT  - Th cells
OT  - Treg cells
OT  - Yiqi Tongyang Decoction
OT  - immune thrombocytopenia
EDAT- 2016/12/10 06:00
MHDA- 2018/06/16 06:00
CRDT- 2016/12/10 06:00
PHST- 2016/03/29 00:00 [received]
PHST- 2016/12/10 06:00 [pubmed]
PHST- 2018/06/16 06:00 [medline]
PHST- 2016/12/10 06:00 [entrez]
AID - 10.1007/s11655-016-2278-7 [pii]
AID - 10.1007/s11655-016-2278-7 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2017 Sep;23(9):709-713. doi: 10.1007/s11655-016-2278-7. Epub 
      2016 Dec 9.