PMID- 27933703
OWN - NLM
STAT- MEDLINE
DCOM- 20171113
LR  - 20220321
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 22
IP  - 4
DP  - 2017 May
TI  - Effects of CPAP therapy on visceral fat thickness, carotid intima-media thickness 
      and adipokines in patients with obstructive sleep apnoea.
PG  - 786-792
LID - 10.1111/resp.12963 [doi]
AB  - BACKGROUND AND OBJECTIVE: Obstructive sleep apnoea (OSA) is associated with an 
      increased prevalence of metabolic syndrome. This study explores the effects of 
      continuous positive airway pressure (CPAP) for patients with OSA on visceral and 
      mesenteric fat thickness, carotid intima-media thickness (IMT) and adipokines. 
      METHODS: A randomized controlled study was conducted at a teaching hospital on 90 
      patients newly diagnosed with OSA to receive either therapeutic CPAP or 
      subtherapeutic CPAP for 3 months. Visceral fat thickness and carotid IMT were 
      measured with B-mode ultrasound; adipokine levels were assessed at baseline and 
      3 months. RESULTS: Altogether, 45 patients received therapeutic CPAP and 45 
      received subtherapeutic CPAP without significant differences in age 50.3 (10.1) 
      versus 48.7 (9.0) years, BMI 28.2 (3.9) versus 28.2 (4.5) kg/m(2) , Epworth 
      Sleepiness Scale (ESS) 12.4 (5.9) versus 11.3 (4.7), apnoea-hypopnoea index (AHI) 
      30.6 (21.4) versus 35.2 (25.5) /h, minimum SaO(2) 79.6 (10.8) versus 76.7 (12.4) 
      % and existing co-morbidities. CPAP usage was therapeutic 4.2 (2.1) versus 
      subtherapeutic 4.1 (2.0) h/night over 3 months. Adiponectin and irisin levels 
      changed significantly following therapeutic CPAP for 3 months versus 
      subtherapeutic CPAP (-1.6 vs 7.3, P = 0.042; 0.1 vs -0.1, P = 0.028 respectively) 
      while only serum level of monocyte chemotactic protein 1 (MCP-1) at baseline was 
      positively correlated with AHI (r = 0.278). No significant changes were observed 
      in other adipokines, visceral fat thickness and IMT. CONCLUSION: Short-term 
      therapeutic CPAP versus subtherapeutic CPAP does not significantly reduce 
      visceral fat thickness and IMT, although it reduces adiponectin and increases 
      irisin.
CI  - (c) 2016 Asian Pacific Society of Respirology.
FAU - Ng, Susanna S S
AU  - Ng SS
AD  - Division of Respiratory Medicine, Department of Medicine and Therapeutics, The 
      Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
FAU - Liu, Eric K H
AU  - Liu EK
AD  - Department of Imaging & Interventional Radiology, The Chinese University of Hong 
      Kong, Prince of Wales Hospital, Shatin, Hong Kong.
FAU - Ma, Ronald C W
AU  - Ma RC
AD  - Division of Respiratory Medicine, Department of Medicine and Therapeutics, The 
      Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
FAU - Chan, Tat-On
AU  - Chan TO
AUID- ORCID: 0000-0002-8163-5846
AD  - Division of Respiratory Medicine, Department of Medicine and Therapeutics, The 
      Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
FAU - To, Kin-Wang
AU  - To KW
AD  - Division of Respiratory Medicine, Department of Medicine and Therapeutics, The 
      Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
FAU - Chan, Ken K P
AU  - Chan KK
AD  - Division of Respiratory Medicine, Department of Medicine and Therapeutics, The 
      Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
FAU - Ngai, Jenny
AU  - Ngai J
AD  - Division of Respiratory Medicine, Department of Medicine and Therapeutics, The 
      Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
FAU - Yip, Wing-Ho
AU  - Yip WH
AD  - Division of Respiratory Medicine, Department of Medicine and Therapeutics, The 
      Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
FAU - Ko, Fanny W S
AU  - Ko FW
AD  - Division of Respiratory Medicine, Department of Medicine and Therapeutics, The 
      Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
FAU - Wong, Chun-Kwok
AU  - Wong CK
AD  - Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of 
      Wales Hospital, Shatin, Hong Kong.
FAU - Hui, David S C
AU  - Hui DS
AD  - Division of Respiratory Medicine, Department of Medicine and Therapeutics, The 
      Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
LA  - eng
SI  - ClinicalTrials.gov/NCT01828281
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161209
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Aged
MH  - *Carotid Intima-Media Thickness
MH  - Comorbidity
MH  - Continuous Positive Airway Pressure/*methods
MH  - Female
MH  - Humans
MH  - Intra-Abdominal Fat/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Polysomnography
MH  - Prospective Studies
MH  - Sleep Apnea, Obstructive/physiopathology/*therapy
OTO - NOTNLM
OT  - adipokines
OT  - carotid intima-media thickness
OT  - continuous positive airway pressure
OT  - obstructive sleep apnoea
OT  - visceral fat thickness
EDAT- 2016/12/10 06:00
MHDA- 2017/11/14 06:00
CRDT- 2016/12/10 06:00
PHST- 2016/04/26 00:00 [received]
PHST- 2016/08/26 00:00 [revised]
PHST- 2016/08/26 00:00 [accepted]
PHST- 2016/12/10 06:00 [pubmed]
PHST- 2017/11/14 06:00 [medline]
PHST- 2016/12/10 06:00 [entrez]
AID - 10.1111/resp.12963 [doi]
PST - ppublish
SO  - Respirology. 2017 May;22(4):786-792. doi: 10.1111/resp.12963. Epub 2016 Dec 9.