PMID- 2794024
OWN - NLM
STAT- MEDLINE
DCOM- 19891031
LR  - 20190908
IS  - 0271-6798 (Print)
IS  - 0271-6798 (Linking)
VI  - 9
IP  - 5
DP  - 1989 Sep-Oct
TI  - Growth-plate cartilage metabolic response to mechanical stress.
PG  - 520-4
AB  - An in vitro study assessing the metabolic response of growth-plate cartilage 
      explants to mechanical stress was performed. Cultured explants were exposed to 
      two types of stress: (a) single high-compressive force (SHC), and (b) multiple 
      intermittent low-compressive force (MILC). Proliferative activity and matrix 
      synthesis were determined with liquid scintillation counting after explants were 
      labeled with [3H]thymidine and [35S]-sulfate. Our in vitro findings suggest that 
      too high a force, even acting for a short time, may result in permanent injury of 
      growth plate cartilage. Hence, we hypothesized that there might be an unknown 
      pathogenetic mechanism of Salter's fifth-type epiphyseal injury. We report the 
      results of our study.
FAU - Greco, F
AU  - Greco F
AD  - Department of Orthopedics, Bioengineering Center, Catholic University of the 
      Sacred Heart, School of Medicine, Rome, Italy.
FAU - de Palma, L
AU  - de Palma L
FAU - Specchia, N
AU  - Specchia N
FAU - Mannarini, M
AU  - Mannarini M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Orthop
JT  - Journal of pediatric orthopedics
JID - 8109053
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Cartilage/*physiology
MH  - Cell Division
MH  - Culture Techniques
MH  - DNA Replication
MH  - *Energy Metabolism
MH  - Growth Plate/*physiology
MH  - *Osteogenesis
MH  - *Physical Exertion
MH  - Physical Stimulation
MH  - Rabbits
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
AID - 10.1097/01241398-198909010-00004 [doi]
PST - ppublish
SO  - J Pediatr Orthop. 1989 Sep-Oct;9(5):520-4. doi: 10.1097/01241398-198909010-00004.