PMID- 27940301
OWN - NLM
STAT- MEDLINE
DCOM- 20171030
LR  - 20221207
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 442
DP  - 2017 Feb 15
TI  - Elevated plasma levels of copeptin linked to diabetic retinopathy in type 2 
      diabetes.
PG  - 106-112
LID - S0303-7207(16)30501-9 [pii]
LID - 10.1016/j.mce.2016.12.003 [doi]
AB  - BACKGROUND: The arginine vasopressin (AVP) system has been postulated to play a 
      role in glucose homeostasis, insulin resistance, and diabetes mellitus in human 
      and animal studies. The aim of this study was to evaluate the role of plasma 
      copeptin in Chinese patients with type 2 diabetes mellitus (T2DM) with and 
      without diabetic retinopathy (DR). METHOD: Plasma copeptin concentrations were 
      determined in 281 patients with T2DM. At baseline, demographic and clinical 
      information including presence of DR and vision-threatening DR (VTDR) was 
      collected. The relationship between copeptin and DR or VTDR was investigated 
      using logistic regression. RESULTS: T2DM participants with DR or VTDR had 
      significantly higher plasma copeptin concentrations on admission (P < 0.0001). 
      Receiver operating characteristics to predict DR and VDTR demonstrated areas 
      under the curve for copeptin of 0.784 (95% confidence interval [CI] 0.724-0.844) 
      and 0.834 (95% CI 0.781-0.904), respectively, which were superior to those for 
      the homeostasis model assessment of insulin resistance (DR AUC 0.736, 95% CI 
      0.676-0.797; VTDR AUC 0.754, 95% CI 0.703-0.828; P < 0.01). Multivariate logistic 
      regression analysis adjusted for common DR risk factors showed plasma copeptin 
      concentrations >/=28.6 pmol/L (>3rd quartile) to be an independent marker of DR (OR 
      3.68, 95% CI 2.04-6.79; P < 0.0001) and VTDR (OR 4.32, 95% CI 2.12-8.14; 
      P < 0.0001). CONCLUSIONS: We found that increased plasma copeptin concentrations 
      were an independent marker of DR and VDTR in Chinese patients with T2DM, 
      suggesting a possible role of copeptin in the pathogenesis of DR complications.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhao, Qi
AU  - Zhao Q
AD  - Department of Ophthalmology, The Second Hospital of Dalian Medical University, 
      Dalian 116023, Liaoning Province, China. Electronic address: pgrosexj91@126.com.
FAU - Wu, Xiao-Xuan
AU  - Wu XX
AD  - Department of Ophthalmology, The Second Hospital of Dalian Medical University, 
      Dalian 116023, Liaoning Province, China.
FAU - Zhou, Jun
AU  - Zhou J
AD  - Department of Ophthalmology, The Second Hospital of Dalian Medical University, 
      Dalian 116023, Liaoning Province, China.
FAU - Wang, Xiao
AU  - Wang X
AD  - Department of Ophthalmology, The Second Hospital of Dalian Medical University, 
      Dalian 116023, Liaoning Province, China.
LA  - eng
PT  - Journal Article
DEP - 20161208
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Biomarkers)
RN  - 0 (Glycopeptides)
RN  - 0 (copeptins)
RN  - 113-79-1 (Arginine Vasopressin)
SB  - IM
MH  - Aged
MH  - Arginine Vasopressin/metabolism
MH  - Asian People
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood/metabolism
MH  - Diabetic Retinopathy/*blood/metabolism
MH  - Female
MH  - Glycopeptides/*blood
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
OTO - NOTNLM
OT  - Copeptin
OT  - Diabetes mellitus
OT  - Diabetic retinopathy
OT  - Vision-threatening diabetic retinopathy
EDAT- 2016/12/13 06:00
MHDA- 2017/10/31 06:00
CRDT- 2016/12/13 06:00
PHST- 2016/08/07 00:00 [received]
PHST- 2016/11/17 00:00 [revised]
PHST- 2016/12/07 00:00 [accepted]
PHST- 2016/12/13 06:00 [pubmed]
PHST- 2017/10/31 06:00 [medline]
PHST- 2016/12/13 06:00 [entrez]
AID - S0303-7207(16)30501-9 [pii]
AID - 10.1016/j.mce.2016.12.003 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2017 Feb 15;442:106-112. doi: 10.1016/j.mce.2016.12.003. 
      Epub 2016 Dec 8.