PMID- 27941910
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Dec 12
TI  - Effects of dextromethorphan on MDMA-induced serotonergic aberration in the brains 
      of non-human primates using [(123)I]-ADAM/SPECT.
PG  - 38695
LID - 10.1038/srep38695 [doi]
LID - 38695
AB  - 3,4-Methylenedioxymethamphetamine (MDMA), a common recreational drug, is known to 
      cause serotonergic neurotoxicity in the brain. Dextromethorphan (DM) is a widely 
      used antitussive reported to exert anti-inflammatory effect in vivo. In this 
      study, we examined the long-term effect of MDMA on the primate serotonergic 
      system and the protective property of DM against MDMA-induced serotonergic 
      abnormality using single photon emission computed tomography (SPECT). Nine 
      monkeys (Macaca cyclopis) were divided into three groups, namely control, MDMA 
      and co-treatment (MDMA/DM). [(123)I]-ADAM was used as the radioligand for 
      serotonin transporters (SERT) in SPECT scans. SERT levels of the brain were 
      evaluated and presented as the uptake ratios (URs) of [(123)I]-ADAM in several 
      regions of interest of the brain including midbrain, thalamus and striatum. We 
      found that the URs of [(123)I]-ADAM were significantly lower in the brains of 
      MDMA than control group, indicating lower brain SERT levels in the MDMA-treated 
      monkeys. This MDMA-induced decrease in brain SERT levels could persist for over 
      four years. However, the loss of brain SERT levels was not observed in 
      co-treatment group. These results suggest that DM may exert a protective effect 
      against MDMA-induced serotonergic toxicity in the brains of the non-human 
      primate.
FAU - Ma, Kuo-Hsing
AU  - Ma KH
AD  - Department of Biology and Anatomy, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Liu, Tsung-Ta
AU  - Liu TT
AD  - Department of Biology and Anatomy, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Weng, Shao-Ju
AU  - Weng SJ
AD  - Department of Biology and Anatomy, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Chen, Chien-Fu F
AU  - Chen CF
AD  - Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Huang, Yuahn-Sieh
AU  - Huang YS
AD  - Department of Biology and Anatomy, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Chueh, Sheau-Huei
AU  - Chueh SH
AD  - Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
FAU - Liao, Mei-Hsiu
AU  - Liao MH
AD  - Institute of Nuclear Energy Research, Taoyuan, Taiwan.
FAU - Chang, Kang-Wei
AU  - Chang KW
AD  - Institute of Nuclear Energy Research, Taoyuan, Taiwan.
FAU - Sung, Chi-Chang
AU  - Sung CC
AD  - Department of Biology and Anatomy, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Hsu, Te-Hung
AU  - Hsu TH
AD  - Department of Biology and Anatomy, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Huang, Wen-Sheng
AU  - Huang WS
AD  - Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Cheng, Cheng-Yi
AU  - Cheng CY
AD  - Department of Nuclear Medicine, Tri-Service General Hospital, National Defense 
      Medical Center, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161212
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine)
RN  - 0 (Iodine Radioisotopes)
RN  - 333DO1RDJY (Serotonin)
RN  - 7355X3ROTS (Dextromethorphan)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - KI6J9OY7A3 (Cinanserin)
SB  - IM
MH  - Animals
MH  - Brain/*diagnostic imaging/drug effects/*metabolism
MH  - Cinanserin/*analogs & derivatives
MH  - Dextromethorphan/*pharmacology
MH  - Iodine Radioisotopes
MH  - Magnetic Resonance Imaging
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Primates
MH  - Serotonin/*metabolism
MH  - Time Factors
MH  - Tomography, Emission-Computed, Single-Photon
PMC - PMC5150522
EDAT- 2016/12/13 06:00
MHDA- 2018/07/17 06:00
PMCR- 2016/12/12
CRDT- 2016/12/13 06:00
PHST- 2016/08/23 00:00 [received]
PHST- 2016/11/11 00:00 [accepted]
PHST- 2016/12/13 06:00 [entrez]
PHST- 2016/12/13 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2016/12/12 00:00 [pmc-release]
AID - srep38695 [pii]
AID - 10.1038/srep38695 [doi]
PST - epublish
SO  - Sci Rep. 2016 Dec 12;6:38695. doi: 10.1038/srep38695.